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1wxl

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{{Seed}}
 
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[[Image:1wxl.png|left|200px]]
 
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==Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT==
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The line below this paragraph, containing "STRUCTURE_1wxl", creates the "Structure Box" on the page.
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<StructureSection load='1wxl' size='340' side='right'caption='[[1wxl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxl OCA], [https://pdbe.org/1wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxl RCSB], [https://www.ebi.ac.uk/pdbsum/1wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxl ProSAT]</span></td></tr>
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{{STRUCTURE_1wxl| PDB=1wxl | SCENE= }}
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</table>
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== Function ==
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===Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT===
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[https://www.uniprot.org/uniprot/SSRP1_DROME SSRP1_DROME] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.<ref>PMID:12815073</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1WXL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxl_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<ref group="xtra">PMID:16041486</ref><references group="xtra"/>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxl ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Hirose, S.]]
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[[Category: Large Structures]]
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[[Category: Kasai, N.]]
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[[Category: Hirose S]]
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[[Category: Morikawa, K.]]
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[[Category: Kasai N]]
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[[Category: Ohki, I.]]
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[[Category: Morikawa K]]
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[[Category: Tate, S.]]
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[[Category: Ohki I]]
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[[Category: Tsunaka, Y.]]
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[[Category: Tate S]]
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[[Category: Fact]]
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[[Category: Tsunaka Y]]
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[[Category: Hmg]]
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[[Category: Ssrp1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:48:47 2009''
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Current revision

Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT

PDB ID 1wxl

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