1lri

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{{Seed}}
 
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[[Image:1lri.png|left|200px]]
 
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==BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1lri", creates the "Structure Box" on the page.
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<StructureSection load='1lri' size='340' side='right'caption='[[1lri]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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{{STRUCTURE_1lri| PDB=1lri | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lri OCA], [https://pdbe.org/1lri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lri RCSB], [https://www.ebi.ac.uk/pdbsum/1lri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lri ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELIB_PHYCR ELIB_PHYCR] Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lri_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lri ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic oomycete Phytophthora cryptogea. The protein also displays a sterol carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit: 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein probably acts as a sterol shuttle helping the pathogen to grow and complete its life cycle.
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===BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX===
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The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site.,Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:12198300<ref>PMID:12198300</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12198300}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1lri" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12198300 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12198300}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1LRI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Phytophthora_cryptogea Phytophthora cryptogea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRI OCA].
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==Reference==
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<ref group="xtra">PMID:12198300</ref><references group="xtra"/>
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[[Category: Phytophthora cryptogea]]
[[Category: Phytophthora cryptogea]]
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[[Category: Blein, J P.]]
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[[Category: Blein J-P]]
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[[Category: Lascombe, M B.]]
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[[Category: Lascombe M-B]]
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[[Category: Milat, M L.]]
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[[Category: Milat M-L]]
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[[Category: Ponchet, M.]]
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[[Category: Ponchet M]]
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[[Category: Prange, T.]]
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[[Category: Prange T]]
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[[Category: Venard, P.]]
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[[Category: Venard P]]
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[[Category: Cholesterol]]
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[[Category: Cryptogein]]
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[[Category: Sterol carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:58:14 2009''
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Current revision

BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX

PDB ID 1lri

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