1sr7

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{{Seed}}
 
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[[Image:1sr7.png|left|200px]]
 
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==Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate==
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The line below this paragraph, containing "STRUCTURE_1sr7", creates the "Structure Box" on the page.
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<StructureSection load='1sr7' size='340' side='right'caption='[[1sr7]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SR7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MOF:MOMETASONE+FUROATE'>MOF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1sr7| PDB=1sr7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sr7 OCA], [https://pdbe.org/1sr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sr7 RCSB], [https://www.ebi.ac.uk/pdbsum/1sr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sr7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sr/1sr7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sr7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although progesterone, the natural ligand of the progesterone receptor (PR), has a hydrogen atom at the 17alpha position, other potent steroid agonists such as norethindrone and mometasone furoate have larger substituents at this position that are accommodated by the PR ligand binding pocket. Crystallographic analysis of PR ligand binding domain complexes clearly demonstrated that these moieties were accommodated by local shifts of the protein main chain and by adoption of alternative side chain rotamer conformations of ligand-proximal amino acids. These conformational changes imparted a ligand-specific volume to the binding pocket, from 490 A3 in the metribolone complex to 520 A3 in the norethindrone complex, 565 A3 in the progesterone complex, and 730 A3 in the mometasone furoate complex. Despite these marked alterations in binding pocket volume, critical interactions essential for establishment of an active AF2 conformation were maintained.
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===Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate===
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Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.,Madauss KP, Deng SJ, Austin RJ, Lambert MH, McLay I, Pritchard J, Short SA, Stewart EL, Uings IJ, Williams SP J Med Chem. 2004 Jun 17;47(13):3381-7. PMID:15189034<ref>PMID:15189034</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1sr7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15189034}}, adds the Publication Abstract to the page
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*[[Progesterone receptor|Progesterone receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15189034 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15189034}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1SR7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR7 OCA].
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==Reference==
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<ref group="xtra">PMID:15189034</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Austin, R J.]]
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[[Category: Large Structures]]
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[[Category: Deng, S J.]]
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[[Category: Austin RJ]]
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[[Category: Lambert, M H.]]
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[[Category: Deng S-J]]
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[[Category: Madauss, K P.]]
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[[Category: Lambert MH]]
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[[Category: McLay, I.]]
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[[Category: Madauss KP]]
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[[Category: Pritchard, J.]]
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[[Category: McLay I]]
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[[Category: Short, S A.]]
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[[Category: Pritchard J]]
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[[Category: Stewart, E L.]]
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[[Category: Short SA]]
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[[Category: Uings, I J.]]
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[[Category: Stewart EL]]
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[[Category: Williams, S P.]]
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[[Category: Uings IJ]]
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[[Category: Hormone receptor]]
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[[Category: Williams SP]]
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[[Category: Mometasone]]
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[[Category: Nuclear receptor]]
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[[Category: Progesterone]]
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[[Category: Progesterone receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:15:40 2009''
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Current revision

Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate

PDB ID 1sr7

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