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1pml

From Proteopedia

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{{Seed}}
 
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[[Image:1pml.png|left|200px]]
 
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<!--
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==KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1pml", creates the "Structure Box" on the page.
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<StructureSection load='1pml' size='340' side='right'caption='[[1pml]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pml]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PML FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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-->
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1pml| PDB=1pml | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pml OCA], [https://pdbe.org/1pml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pml RCSB], [https://www.ebi.ac.uk/pdbsum/1pml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pml ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
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== Function ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/1pml_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pml ConSurf].
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<div style="clear:both"></div>
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===KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES===
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==See Also==
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*[[Plasminogen 3D structures|Plasminogen 3D structures]]
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*[[Plasminogen activator|Plasminogen activator]]
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_8069221}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 8069221 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_8069221}}
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==About this Structure==
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1PML is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PML OCA].
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==Reference==
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<ref group="xtra">PMID:8069221</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: T-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Padmanabhan, K.]]
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[[Category: Padmanabhan K]]
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[[Category: Tulinsky, A.]]
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[[Category: Tulinsky A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:19:56 2009''
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Current revision

KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES

PDB ID 1pml

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