1wqj

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{{Seed}}
 
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[[Image:1wqj.png|left|200px]]
 
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==Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)==
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The line below this paragraph, containing "STRUCTURE_1wqj", creates the "Structure Box" on the page.
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<StructureSection load='1wqj' size='340' side='right'caption='[[1wqj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WQJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wqj OCA], [https://pdbe.org/1wqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wqj RCSB], [https://www.ebi.ac.uk/pdbsum/1wqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wqj ProSAT]</span></td></tr>
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{{STRUCTURE_1wqj| PDB=1wqj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/1wqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wqj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Insulin-like growth factor binding proteins (IGFBPs) control the extracellular distribution, function, and activity of IGFs. Here, we report an X-ray structure of the binary complex of IGF-I and the N-terminal domain of IGFBP-4 (NBP-4, residues 3-82) and a model of the ternary complex of IGF-I, NBP-4, and the C-terminal domain (CBP-4, residues 151-232) derived from diffraction data with weak definition of the C-terminal domain. These structures show how the IGFBPs regulate IGF signaling. Key features of the structures include (1) a disulphide bond ladder that binds to IGF and partially masks the IGF residues responsible for type 1 IGF receptor (IGF-IR) binding, (2) the high-affinity IGF-I interaction site formed by residues 39-82 in a globular fold, and (3) CBP-4 interactions. Although CBP-4 does not bind individually to either IGF-I or NBP-4, in the ternary complex, CBP-4 contacts both and also blocks the IGF-IR binding region of IGF-I.
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===Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)===
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Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.,Siwanowicz I, Popowicz GM, Wisniewska M, Huber R, Kuenkele KP, Lang K, Engh RA, Holak TA Structure. 2005 Jan;13(1):155-67. PMID:15642270<ref>PMID:15642270</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wqj" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15642270}}, adds the Publication Abstract to the page
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*[[Insulin-like growth factor|Insulin-like growth factor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15642270 is the PubMed ID number.
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*[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_15642270}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1WQJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQJ OCA].
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==Reference==
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<ref group="xtra">PMID:15642270</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Engh, R A.]]
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[[Category: Large Structures]]
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[[Category: Holak, T A.]]
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[[Category: Engh RA]]
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[[Category: Huber, R.]]
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[[Category: Holak TA]]
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[[Category: Kuenkele, K P.]]
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[[Category: Huber R]]
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[[Category: Lang, K.]]
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[[Category: Kuenkele KP]]
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[[Category: Popowicz, G M.]]
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[[Category: Lang K]]
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[[Category: Siwanowicz, I.]]
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[[Category: Popowicz GM]]
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[[Category: Wisniewska, M.]]
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[[Category: Siwanowicz I]]
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[[Category: Disulfide bond ladder]]
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[[Category: Wisniewska M]]
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[[Category: Disulfide rich]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:20:23 2009''
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Current revision

Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)

PDB ID 1wqj

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