1uh0

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{{Seed}}
 
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[[Image:1uh0.png|left|200px]]
 
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==Crystal structure of jacalin- Me-alpha-GalNAc complex==
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The line below this paragraph, containing "STRUCTURE_1uh0", creates the "Structure Box" on the page.
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<StructureSection load='1uh0' size='340' side='right'caption='[[1uh0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uh0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UH0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGC:ALPHA-METHYL-N-ACETYL-D-GALACTOSAMINE'>MGC</scene></td></tr>
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{{STRUCTURE_1uh0| PDB=1uh0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uh0 OCA], [https://pdbe.org/1uh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1uh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uh0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uh0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uh0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of the complexes of tetrameric jacalin with Gal, Me-alpha-GalNAc, Me-alpha-T-antigen, GalNAcbeta1-3Gal-alpha-O-Me and Galalpha1-6Glc (mellibiose) show that the sugar-binding site of jacalin has three components: the primary site, secondary site A, and secondary site B. In these structures and in the two structures reported earlier, Gal or GalNAc occupy the primary site with the anomeric carbon pointing towards secondary site A. The alpha-substituents, when present, interact, primarily hydrophobically, with secondary site A which has variable geometry. O-H..., centered pi and C-H...pi hydrogen bonds involving this site also exist. On the other hand, beta-substitution leads to severe steric clashes. Therefore, in complexes involving beta-linked disaccharides, the reducing sugar binds at the primary site with the non-reducing end located at secondary site B. The interactions at secondary site B are primarily through water bridges. Thus, the nature of the linkage determines the mode of the association of the sugar with jacalin. The interactions observed in the crystal structures and modeling based on them provide a satisfactory qualitative explanation of the available thermodynamic data on jacalin-carbohydrate interactions. They also lead to fresh insights into the nature of the binding of glycoproteins by jacalin.
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===Crystal structure of jacalin- Me-alpha-GalNAc complex===
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Structural basis of the carbohydrate specificities of jacalin: an X-ray and modeling study.,Jeyaprakash AA, Katiyar S, Swaminathan CP, Sekar K, Surolia A, Vijayan M J Mol Biol. 2003 Sep 5;332(1):217-28. PMID:12946359<ref>PMID:12946359</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1uh0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12946359}}, adds the Publication Abstract to the page
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12946359 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12946359}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Artocarpus integer]]
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1UH0 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Artocarpus_integrifolia Artocarpus integrifolia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UH0 OCA].
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[[Category: Large Structures]]
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[[Category: Jeyaprakash AA]]
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==Reference==
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[[Category: Katiyar S]]
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<ref group="xtra">PMID:12946359</ref><references group="xtra"/>
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[[Category: Sekar K]]
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[[Category: Artocarpus integrifolia]]
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[[Category: Surolia A]]
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[[Category: Jeyaprakash, A A.]]
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[[Category: Swaminathan CP]]
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[[Category: Katiyar, S.]]
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[[Category: Vijayan M]]
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[[Category: Sekar, K.]]
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[[Category: Surolia, A.]]
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[[Category: Swaminathan, C P.]]
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[[Category: Vijayan, M.]]
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[[Category: All beta sheet protein]]
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[[Category: Beta-prism i fold]]
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[[Category: Gal specific]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:25:15 2009''
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Current revision

Crystal structure of jacalin- Me-alpha-GalNAc complex

PDB ID 1uh0

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