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1jy8

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{{Seed}}
 
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[[Image:1jy8.png|left|200px]]
 
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==2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)==
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The line below this paragraph, containing "STRUCTURE_1jy8", creates the "Structure Box" on the page.
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<StructureSection load='1jy8' size='340' side='right'caption='[[1jy8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jy8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JY8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CDI:2C-METHYL-D-ERYTHRITOL+2,4-CYCLODIPHOSPHATE'>CDI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1jy8| PDB=1jy8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy8 OCA], [https://pdbe.org/1jy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jy8 RCSB], [https://www.ebi.ac.uk/pdbsum/1jy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jy8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jy8 ConSurf].
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<div style="clear:both"></div>
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===2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)===
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==See Also==
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*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11829504}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11829504 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11829504}}
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==About this Structure==
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1JY8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY8 OCA].
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==Reference==
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<ref group="xtra">PMID:11829504</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bacher, A.]]
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[[Category: Large Structures]]
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[[Category: Eisenreich, W.]]
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[[Category: Bacher A]]
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[[Category: Gerhardt, S.]]
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[[Category: Eisenreich W]]
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[[Category: Hecht, S.]]
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[[Category: Gerhardt S]]
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[[Category: Kaiser, J.]]
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[[Category: Hecht S]]
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[[Category: Rohdich, F.]]
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[[Category: Kaiser J]]
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[[Category: Steinbacher, S.]]
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[[Category: Rohdich F]]
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[[Category: Wungsintaweekul, J.]]
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[[Category: Steinbacher S]]
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[[Category: Drug design]]
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[[Category: Wungsintaweekul J]]
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[[Category: Isoprenoid biosynthesis]]
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[[Category: Malaria]]
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[[Category: Terpene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:35:43 2009''
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Current revision

2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)

PDB ID 1jy8

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