2a20

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{{Seed}}
 
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[[Image:2a20.png|left|200px]]
 
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==Solution structure of Rim2 Zinc Finger Domain==
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The line below this paragraph, containing "STRUCTURE_2a20", creates the "Structure Box" on the page.
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<StructureSection load='2a20' size='340' side='right'caption='[[2a20]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A20 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2a20| PDB=2a20 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a20 OCA], [https://pdbe.org/2a20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a20 RCSB], [https://www.ebi.ac.uk/pdbsum/2a20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a20 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIMS2_RAT RIMS2_RAT] Rab effector involved in exocytosis. May act as scaffold protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a20_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a20 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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alpha-RIMs and Munc13s are active zone proteins that control priming of synaptic vesicles to a readily releasable state, and interact with each other via their N-terminal sequences. The alpha-RIM N-terminal sequence also binds to Rab3s (small synaptic vesicle GTPases), an interaction that regulates presynaptic plasticity. We now demonstrate that alpha-RIMs contain adjacent but separate Munc13- and Rab3-binding sites, allowing formation of a tripartite Rab3/RIM/Munc13 complex. Munc13 binding is mediated by the alpha-RIM zinc-finger domain. Elucidation of the three-dimensional structure of this domain by NMR spectroscopy facilitated the design of a mutation that abolishes alpha-RIM/Munc13 binding. Selective disruption of this interaction in the calyx of Held synapse decreased the size of the readily releasable vesicle pool. Our data suggest that the ternary Rab3/RIM/Munc13 interaction approximates synaptic vesicles to the priming machinery, providing a substrate for presynaptic plasticity. The modular architecture of alpha-RIMs, with nested binding sites for Rab3 and other targets, may be a general feature of Rab effectors that share homology with the alpha-RIM N-terminal sequence.
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===Solution structure of Rim2 Zinc Finger Domain===
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A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?,Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Sudhof TC, Rizo J EMBO J. 2005 Aug 17;24(16):2839-50. Epub 2005 Jul 28. PMID:16052212<ref>PMID:16052212</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16052212}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2a20" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16052212 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16052212}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2A20 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A20 OCA].
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==Reference==
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<ref group="xtra">PMID:16052212</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Alam, A.]]
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[[Category: Alam A]]
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[[Category: Dulubova, I.]]
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[[Category: Dulubova I]]
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[[Category: Huryeva, I.]]
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[[Category: Huryeva I]]
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[[Category: Lou, X.]]
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[[Category: Lou X]]
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[[Category: Lu, J.]]
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[[Category: Lu J]]
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[[Category: Rizo, J.]]
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[[Category: Rizo J]]
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[[Category: Schneggenburger, R.]]
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[[Category: Schneggenburger R]]
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[[Category: Sudhof, T C.]]
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[[Category: Sudhof TC]]
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[[Category: Zinc-finger domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:54:14 2009''
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Current revision

Solution structure of Rim2 Zinc Finger Domain

PDB ID 2a20

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