2bzu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2bzu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bzu, resolution 1.50&Aring;" /> '''HUMAN ADENOVIRUS SER...)
Current revision (13:59, 13 December 2023) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2bzu.gif|left|200px]]<br /><applet load="2bzu" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2bzu, resolution 1.50&Aring;" />
 
-
'''HUMAN ADENOVIRUS SEROTYPE 41 FIBER HEAD'''<br />
 
-
==Overview==
+
==Human Adenovirus Serotype 41 Fiber Head==
-
Human enteric adenoviruses of species F contain two fibers in the same, virion, a long fiber which binds to coxsackievirus and adenovirus receptor, (CAR) and a short fiber of unknown function. We have determined the, high-resolution crystal structure of the short fiber head of human, adenovirus serotype 41 (Ad41). The short fiber head has the characteristic, fold of other known fiber heads but has three unusual features. First, it, has much shorter loops between the beta-strands. Second, one of the, usually well-ordered beta-strands on the distal face of the fiber head is, highly disordered and this same region is sensitive to digestion with, pepsin, an enzyme occurring naturally in the intestinal tract, the, physiological environment of Ad41. Third, the AB loop has a deletion, giving it a distinct conformation incompatible with CAR binding.
+
<StructureSection load='2bzu' size='340' side='right'caption='[[2bzu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2bzu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_41 Human adenovirus 41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZU FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzu OCA], [https://pdbe.org/2bzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzu RCSB], [https://www.ebi.ac.uk/pdbsum/2bzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzu ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SPIK2_ADE41 SPIK2_ADE41] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzu_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bzu ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.
-
==About this Structure==
+
Crystal structure of enteric adenovirus serotype 41 short fiber head.,Seiradake E, Cusack S J Virol. 2005 Nov;79(22):14088-94. PMID:16254343<ref>PMID:16254343</ref>
-
2BZU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_37 Human adenovirus 37]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BZU OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Crystal structure of enteric adenovirus serotype 41 short fiber head., Seiradake E, Cusack S, J Virol. 2005 Nov;79(22):14088-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16254343 16254343]
+
</div>
-
[[Category: Human adenovirus 37]]
+
<div class="pdbe-citations 2bzu" style="background-color:#fffaf0;"></div>
-
[[Category: Single protein]]
+
== References ==
-
[[Category: Cusack, S.]]
+
<references/>
-
[[Category: Seiradake, E.]]
+
__TOC__
-
[[Category: ad41]]
+
</StructureSection>
-
[[Category: adenovirus]]
+
[[Category: Human adenovirus 41]]
-
[[Category: fiber]]
+
[[Category: Large Structures]]
-
[[Category: fiber protein]]
+
[[Category: Cusack S]]
-
[[Category: receptor]]
+
[[Category: Seiradake E]]
-
[[Category: viral protein]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:58:15 2007''
+

Current revision

Human Adenovirus Serotype 41 Fiber Head

PDB ID 2bzu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bzu"
Personal tools