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1ma3

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{{Seed}}
 
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[[Image:1ma3.png|left|200px]]
 
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<!--
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==Structure of a Sir2 enzyme bound to an acetylated p53 peptide==
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The line below this paragraph, containing "STRUCTURE_1ma3", creates the "Structure Box" on the page.
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<StructureSection load='1ma3' size='340' side='right'caption='[[1ma3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ma3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MA3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1ma3| PDB=1ma3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ma3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ma3 OCA], [https://pdbe.org/1ma3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ma3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ma3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ma3 ProSAT]</span></td></tr>
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</table>
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===Structure of a Sir2 enzyme bound to an acetylated p53 peptide===
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== Function ==
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[https://www.uniprot.org/uniprot/NPD2_ARCFU NPD2_ARCFU] NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription (By similarity).[HAMAP-Rule:MF_01121]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12408821 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ma/1ma3_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12408821}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1MA3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MA3 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ma3 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:12408821</ref><references group="xtra"/>
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</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Avalos, J L.]]
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[[Category: Homo sapiens]]
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[[Category: Boeke, J D.]]
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[[Category: Large Structures]]
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[[Category: Celic, I.]]
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[[Category: Avalos JL]]
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[[Category: Cosgrove, M S.]]
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[[Category: Boeke JD]]
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[[Category: Muhammad, S.]]
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[[Category: Celic I]]
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[[Category: Wolberger, C.]]
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[[Category: Cosgrove MS]]
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[[Category: Enzyme-substrate complex]]
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[[Category: Muhammad S]]
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[[Category: Wolberger C]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:59:01 2009''
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Current revision

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

PDB ID 1ma3

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