1z9m

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{{Seed}}
 
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[[Image:1z9m.png|left|200px]]
 
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==Crystal Structure of Nectin-like molecule-1 protein Domain 1==
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The line below this paragraph, containing "STRUCTURE_1z9m", creates the "Structure Box" on the page.
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<StructureSection load='1z9m' size='340' side='right'caption='[[1z9m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9m OCA], [https://pdbe.org/1z9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9m RCSB], [https://www.ebi.ac.uk/pdbsum/1z9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9m ProSAT]</span></td></tr>
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{{STRUCTURE_1z9m| PDB=1z9m | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CADM3_HUMAN CADM3_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CADM3_HUMAN CADM3_HUMAN] Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).[UniProtKB:Q99N28]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z9m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z9m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nectins are Ca(2+)-independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions. Nectins have three Ig-like domains in the extracellular region, and the first one is essential in cell-cell adhesion and plays a central role in the interaction with the envelope glycoprotein D of several viruses. Five Nectin-like molecules (Necl-1 through -5) with similar domain structures to those of Nectins have been identified. Necl-1 is specifically expressed in neural tissue, has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity, and plays an important role in the formation of synapses, axon bundles, and myelinated axons. Here we report the first crystal structure of its N-terminal Ig-like V domain at 2.4 A, providing insight into trans-cellular recognition mediated by Necl-1. The protein crystallized as a dimer, and the dimeric form was confirmed by size-exclusion chromatography and chemical cross-linking experiments, indicating this V domain is sufficient for homophilic interaction. Mutagenesis work demonstrated that Phe(82) is a key residue for the adhesion activity of Necl-1. A model for homophilic adhesion of Necl-1 at synapses is proposed based on its structure and previous studies.
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===Crystal Structure of Nectin-like molecule-1 protein Domain 1===
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Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.,Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Peng Y, Qiang B, Yuan J, Peng X, Rao Z J Biol Chem. 2006 Apr 14;281(15):10610-7. Epub 2006 Feb 7. PMID:16467305<ref>PMID:16467305</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16467305}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1z9m" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16467305 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16467305}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z9M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9M OCA].
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==Reference==
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<ref group="xtra">PMID:16467305</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, T.]]
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[[Category: Large Structures]]
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[[Category: Dong, X.]]
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[[Category: Chen T]]
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[[Category: Gao, J.]]
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[[Category: Dong X]]
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[[Category: Gong, Y.]]
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[[Category: Gao J]]
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[[Category: Lin, P.]]
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[[Category: Gong Y]]
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[[Category: Peng, X.]]
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[[Category: Lin P]]
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[[Category: Peng, Y.]]
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[[Category: Peng X]]
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[[Category: Qiang, B.]]
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[[Category: Peng Y]]
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[[Category: Rao, Z.]]
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[[Category: Qiang B]]
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[[Category: Xu, F.]]
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[[Category: Rao Z]]
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[[Category: Yuan, J.]]
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[[Category: Xu F]]
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[[Category: Ig-like domain]]
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[[Category: Yuan J]]
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[[Category: Nectin-like]]
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[[Category: V domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:01:42 2009''
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Current revision

Crystal Structure of Nectin-like molecule-1 protein Domain 1

PDB ID 1z9m

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