1ssf

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{{Seed}}
 
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[[Image:1ssf.png|left|200px]]
 
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==Solution structure of the mouse 53BP1 fragment (residues 1463-1617)==
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The line below this paragraph, containing "STRUCTURE_1ssf", creates the "Structure Box" on the page.
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<StructureSection load='1ssf' size='340' side='right'caption='[[1ssf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ssf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssf OCA], [https://pdbe.org/1ssf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssf RCSB], [https://www.ebi.ac.uk/pdbsum/1ssf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssf ProSAT]</span></td></tr>
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{{STRUCTURE_1ssf| PDB=1ssf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TP53B_MOUSE TP53B_MOUSE] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation (By similarity).<ref>PMID:11801725</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ssf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ssf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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53BP1 is a key transducer of the DNA damage checkpoint signal, which is required for phosphorylation of a subset of ATM substrates and p53 accumulation. After cell irradiation, the 53BP1 N-terminal region is phosphorylated. Its two C-terminal BRCT motifs interact with p53. Its central region is required and sufficient for 53BP1 foci formation at DNA strand breaks and for 53BP1 binding to the kinetochore. It contains an RG-rich segment and interacts with DNA in vitro. Here we show that the major globular domain of the 53BP1 central region adopts a new structural motif composed of two tightly packed Tudor domains and a C-terminal alpha helix. A unique surface essentially located on the first Tudor domain is involved in the binding to 53BP1 RG-rich sequence and to DNA, suggesting that the Tudor tandem can act as an adaptor mediating intramolecular as well as intermolecular protein-protein interactions and protein-nucleic acid associations.
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===Solution structure of the mouse 53BP1 fragment (residues 1463-1617)===
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The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding.,Charier G, Couprie J, Alpha-Bazin B, Meyer V, Quemeneur E, Guerois R, Callebaut I, Gilquin B, Zinn-Justin S Structure. 2004 Sep;12(9):1551-62. PMID:15341721<ref>PMID:15341721</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15341721}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ssf" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15341721 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15341721}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1SSF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSF OCA].
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==Reference==
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<ref group="xtra">PMID:15341721</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Alpha-Bazin, B.]]
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[[Category: Alpha-Bazin B]]
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[[Category: Callebaut, I.]]
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[[Category: Callebaut I]]
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[[Category: Charier, G.]]
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[[Category: Charier G]]
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[[Category: Couprie, J.]]
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[[Category: Couprie J]]
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[[Category: Gilquin, B.]]
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[[Category: Gilquin B]]
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[[Category: Guerois, R.]]
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[[Category: Guerois R]]
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[[Category: Meyer, V.]]
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[[Category: Meyer V]]
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[[Category: Quemeneur, E.]]
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[[Category: Quemeneur E]]
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[[Category: Zinn-Justin, S.]]
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[[Category: Zinn-Justin S]]
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[[Category: Alpha-helix]]
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[[Category: Beta barrel]]
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[[Category: Sh3-like fold]]
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[[Category: Tandem]]
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[[Category: Tudor domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:02:41 2009''
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Current revision

Solution structure of the mouse 53BP1 fragment (residues 1463-1617)

PDB ID 1ssf

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OCA

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