1nm3

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{{Seed}}
 
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[[Image:1nm3.png|left|200px]]
 
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==Crystal structure of Heamophilus influenza hybrid-Prx5==
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The line below this paragraph, containing "STRUCTURE_1nm3", creates the "Structure Box" on the page.
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<StructureSection load='1nm3' size='340' side='right'caption='[[1nm3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NM3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1nm3| PDB=1nm3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nm3 OCA], [https://pdbe.org/1nm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nm3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nm3 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nm/1nm3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nm3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cellular redox control is often mediated by oxidation and reduction of cysteine residues in the redox-sensitive proteins, where thioredoxin and glutaredoxin (Grx) play as electron donors for the oxidized proteins. Despite the importance of protein-protein interactions between the electron donor and acceptor proteins, there has been no structural information for the interaction of thioredoxin or Grx with natural target proteins. Here, we present the crystal structure of a novel Haemophilus influenza peroxiredoxin (Prx) hybrid Prx5 determined at 2.8-A resolution. The structure reveals that hybrid Prx5 forms a tightly associated tetramer where active sites of Prx and Grx domains of different monomers interact with each other. The Prx-Grx interface comprises specific charge interactions surrounded by weak interactions, providing insight into the target recognition mechanism of Grx. The tetrameric structure also exhibits a flexible active site and alternative Prx-Grx interactions, which appear to facilitate the electron transfer from Grx to Prx domain. Differences of electron donor binding surfaces in Prx proteins revealed by an analysis based on the structural information explain the electron donor specificities of various Prx proteins.
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===Crystal structure of Heamophilus influenza hybrid-Prx5===
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The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins.,Kim SJ, Woo JR, Hwang YS, Jeong DG, Shin DH, Kim K, Ryu SE J Biol Chem. 2003 Mar 21;278(12):10790-8. Epub 2003 Jan 14. PMID:12529327<ref>PMID:12529327</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12529327}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1nm3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12529327 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12529327}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1NM3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM3 OCA].
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==Reference==
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<ref group="xtra">PMID:12529327</ref><references group="xtra"/>
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Hwang, Y S.]]
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[[Category: Large Structures]]
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[[Category: Jeong, D G.]]
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[[Category: Hwang YS]]
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[[Category: Kim, K H.]]
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[[Category: Jeong DG]]
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[[Category: Kim, S J.]]
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[[Category: Kim KH]]
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[[Category: Ryu, S E.]]
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[[Category: Kim SJ]]
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[[Category: Shin, D H.]]
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[[Category: Ryu SE]]
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[[Category: Woo, J R.]]
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[[Category: Shin DH]]
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[[Category: Glutaredoxin]]
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[[Category: Woo JR]]
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[[Category: Hybrid]]
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[[Category: Peroxiredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:08:52 2009''
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Current revision

Crystal structure of Heamophilus influenza hybrid-Prx5

PDB ID 1nm3

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