1tqm

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{{Seed}}
 
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[[Image:1tqm.png|left|200px]]
 
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==Crystal Structure of A. fulgidus Rio2 Serine Protein Kinase Bound to AMPPNP==
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The line below this paragraph, containing "STRUCTURE_1tqm", creates the "Structure Box" on the page.
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<StructureSection load='1tqm' size='340' side='right'caption='[[1tqm]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
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{{STRUCTURE_1tqm| PDB=1tqm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqm OCA], [https://pdbe.org/1tqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqm RCSB], [https://www.ebi.ac.uk/pdbsum/1tqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIO2_ARCFU RIO2_ARCFU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serine phosphorylation in vitro, and the presence of conserved catalytic residues is required for cell viability. The activity of Rio2 is necessary for rRNA cleavage in 40S ribosomal subunit maturation. We solved the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 A resolution. The C-terminal RIO domain is indeed structurally homologous to protein kinases, although it differs from known serine kinases in ATP binding and lacks the regions important for substrate binding. Unexpectedly, the N-terminal Rio2-specific domain contains a winged helix fold, seen primarily in DNA-binding proteins. These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases.
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===Crystal Structure of A. fulgidus Rio2 Serine Protein Kinase Bound to AMPPNP===
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Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases.,LaRonde-LeBlanc N, Wlodawer A Structure. 2004 Sep;12(9):1585-94. PMID:15341724<ref>PMID:15341724</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15341724}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1tqm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15341724 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15341724}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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1TQM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQM OCA].
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[[Category: Large Structures]]
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[[Category: LaRonde-LeBlanc N]]
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==Reference==
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[[Category: Wlodawer A]]
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<ref group="xtra">PMID:15341724</ref><references group="xtra"/>
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[[Category: Archaeoglobus fulgidus dsm 4304]]
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[[Category: LaRonde-LeBlanc, N.]]
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[[Category: Wlodawer, A.]]
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[[Category: Amppnp]]
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[[Category: Anp]]
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[[Category: Serine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:13:47 2009''
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Current revision

Crystal Structure of A. fulgidus Rio2 Serine Protein Kinase Bound to AMPPNP

PDB ID 1tqm

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