1mem

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:38, 6 November 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1mem.png|left|200px]]
 
-
<!--
+
==Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor==
-
The line below this paragraph, containing "STRUCTURE_1mem", creates the "Structure Box" on the page.
+
<StructureSection load='1mem' size='340' side='right'caption='[[1mem]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1mem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0D6:N-{(1R)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-N~2~-(PIPERAZIN-1-YLCARBONYL)-L-LEUCINAMIDE'>0D6</scene></td></tr>
-
{{STRUCTURE_1mem| PDB=1mem | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mem OCA], [https://pdbe.org/1mem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mem RCSB], [https://www.ebi.ac.uk/pdbsum/1mem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mem ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/1mem_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mem ConSurf].
 +
<div style="clear:both"></div>
-
===CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR===
+
==See Also==
-
 
+
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1MEM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
-
<ref group="xtra">PMID:9033587</ref><references group="xtra"/>
+
-
[[Category: Cathepsin K]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Mcgrath, M E.]]
+
[[Category: Large Structures]]
-
[[Category: Cysteine]]
+
[[Category: Mcgrath ME]]
-
[[Category: Drug design]]
+
-
[[Category: Osteoclast]]
+
-
[[Category: Osteoporosis]]
+
-
[[Category: Protease]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:14:15 2009''
+

Current revision

Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor

PDB ID 1mem

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mem"
Personal tools