1z8d

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{{Seed}}
 
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[[Image:1z8d.png|left|200px]]
 
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==Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose==
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The line below this paragraph, containing "STRUCTURE_1z8d", creates the "Structure Box" on the page.
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<StructureSection load='1z8d' size='340' side='right'caption='[[1z8d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_1z8d| PDB=1z8d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [https://pdbe.org/1z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB], [https://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8d ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[https://omim.org/entry/232600 232600]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref> <ref>PMID:8535454</ref> <ref>PMID:7603523</ref> <ref>PMID:9506549</ref> <ref>PMID:10417800</ref> <ref>PMID:10382911</ref> <ref>PMID:10382912</ref> <ref>PMID:10681080</ref> <ref>PMID:10590419</ref> <ref>PMID:10714589</ref> <ref>PMID:10899452</ref> <ref>PMID:11706962</ref> <ref>PMID:12031624</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8d ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose===
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==See Also==
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*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: McArdle disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608455 608455]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z8D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA].
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==Reference==
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<ref group="xtra">PMID:16523484</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Crowther, R L.]]
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[[Category: Crowther RL]]
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[[Category: Hong, L N.]]
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[[Category: Hong LN]]
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[[Category: Kammlott, R U.]]
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[[Category: Kammlott RU]]
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[[Category: Levin, W.]]
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[[Category: Levin W]]
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[[Category: Li, S.]]
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[[Category: Li S]]
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[[Category: Liu, C M.]]
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[[Category: Liu CM]]
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[[Category: Lucas-McGady, D.]]
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[[Category: Lucas-McGady D]]
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[[Category: Lukacs, C M.]]
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[[Category: Lukacs CM]]
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[[Category: Oikonomakos, N G.]]
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[[Category: Oikonomakos NG]]
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[[Category: Pietranico, S.]]
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[[Category: Pietranico S]]
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[[Category: Reik, L.]]
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[[Category: Reik L]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:31:56 2009''
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Current revision

Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose

PDB ID 1z8d

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