3rpb

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{{Seed}}
 
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[[Image:3rpb.png|left|200px]]
 
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==THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN==
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The line below this paragraph, containing "STRUCTURE_3rpb", creates the "Structure Box" on the page.
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<StructureSection load='3rpb' size='340' side='right'caption='[[3rpb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RPB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rpb OCA], [https://pdbe.org/3rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rpb RCSB], [https://www.ebi.ac.uk/pdbsum/3rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rpb ProSAT]</span></td></tr>
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{{STRUCTURE_3rpb| PDB=3rpb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/3rpb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3rpb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C2 domains are widespread protein modules that often occur as tandem repeats in many membrane-trafficking proteins such as synaptotagmin and rabphilin. The first and second C2 domains (C2A and C2B, respectively) have a high degree of homology but also specific differences. The structure of the C2A domain of synaptotagmin I has been extensively studied but little is known about the C2B domains. We have used NMR spectroscopy to determine the solution structure of the C2B domain of rabphilin. The overall structure of the C2B domain is very similar to that of other C2 domains, with a rigid beta-sandwich core and loops at the top (where Ca2+ binds) and the bottom. Surprisingly, a relatively long alpha-helix is inserted at the bottom of the domain and is conserved in all C2B domains. Our results, together with the Ca(2+)-independent interactions observed for C2B domains, indicate that these domains have a Janus-faced nature, with a Ca(2+)-binding top surface and a Ca(2+)-independent bottom surface.
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===THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN===
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Structure of the Janus-faced C2B domain of rabphilin.,Ubach J, Garcia J, Nittler MP, Sudhof TC, Rizo J Nat Cell Biol. 1999 Jun;1(2):106-12. PMID:10559882<ref>PMID:10559882</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rpb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10559882}}, adds the Publication Abstract to the page
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*[[Exophilin 3D structures|Exophilin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10559882 is the PubMed ID number.
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*[[Rabphilin|Rabphilin]]
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== References ==
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{{ABSTRACT_PUBMED_10559882}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3RPB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RPB OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:10559882</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Garcia, J.]]
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[[Category: Garcia J]]
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[[Category: Nittler, M P.]]
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[[Category: Nittler MP]]
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[[Category: Rizo, J.]]
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[[Category: Rizo J]]
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[[Category: Sudhof, T C.]]
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[[Category: Sudhof TC]]
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[[Category: Ubach, J.]]
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[[Category: Ubach J]]
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[[Category: C2-domain]]
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[[Category: C2b-domain]]
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[[Category: Rabphilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:32:43 2009''
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Current revision

THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN

PDB ID 3rpb

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