2ckb

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(New page: 200px<br /><applet load="2ckb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ckb, resolution 3.0&Aring;" /> '''STRUCTURE OF THE 2C/K...)
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[[Image:2ckb.gif|left|200px]]<br /><applet load="2ckb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ckb, resolution 3.0&Aring;" />
 
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'''STRUCTURE OF THE 2C/KB/DEV8 COMPLEX'''<br />
 
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==Overview==
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==STRUCTURE OF THE 2C/KB/DEV8 COMPLEX==
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The T cell receptor (TCR) inherently has dual specificity. T cells must, recognize self-antigens in the thymus during maturation and then, discriminate between foreign pathogens in the periphery. A molecular basis, for this cross-reactivity is elucidated by the crystal structure of the, alloreactive 2C TCR bound to self peptide-major histocompatibility complex, (pMHC) antigen H-2Kb-dEV8 refined against anisotropic 3.0 angstrom, resolution x-ray data. The interface between peptide and TCR exhibits, extremely poor shape complementarity, and the TCR beta chain, complementarity-determining region 3 (CDR3) has minimal interaction with, the dEV8 peptide. Large conformational changes in three of the TCR CDR, loops are induced upon binding, providing a mechanism of structural, plasticity to accommodate a variety of different peptide antigens., Extensive TCR interaction with the pMHC alpha helices suggests a, generalized orientation that is mediated by the Valpha domain of the TCR, and rationalizes how TCRs can effectively "scan" different peptides bound, within a large, low-affinity MHC structural framework for those that, provide the slight additional kinetic stabilization required for, signaling.
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<StructureSection load='2ckb' size='340' side='right'caption='[[2ckb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ckb]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The March 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''T-Cell Receptor'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_3 10.2210/rcsb_pdb/mom_2005_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ckb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckb OCA], [https://pdbe.org/2ckb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ckb RCSB], [https://www.ebi.ac.uk/pdbsum/2ckb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ckb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ckb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation and then discriminate between foreign pathogens in the periphery. A molecular basis for this cross-reactivity is elucidated by the crystal structure of the alloreactive 2C TCR bound to self peptide-major histocompatibility complex (pMHC) antigen H-2Kb-dEV8 refined against anisotropic 3.0 angstrom resolution x-ray data. The interface between peptide and TCR exhibits extremely poor shape complementarity, and the TCR beta chain complementarity-determining region 3 (CDR3) has minimal interaction with the dEV8 peptide. Large conformational changes in three of the TCR CDR loops are induced upon binding, providing a mechanism of structural plasticity to accommodate a variety of different peptide antigens. Extensive TCR interaction with the pMHC alpha helices suggests a generalized orientation that is mediated by the Valpha domain of the TCR and rationalizes how TCRs can effectively "scan" different peptides bound within a large, low-affinity MHC structural framework for those that provide the slight additional kinetic stabilization required for signaling.
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==About this Structure==
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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.,Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA Science. 1998 Feb 20;279(5354):1166-72. PMID:9469799<ref>PMID:9469799</ref>
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2CKB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CKB OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen., Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA, Science. 1998 Feb 20;279(5354):1166-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9469799 9469799]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 2ckb" style="background-color:#fffaf0;"></div>
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[[Category: Protein complex]]
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[[Category: Degano, M.]]
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[[Category: Garcia, K.C.]]
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[[Category: Wilson, I.A.]]
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[[Category: major histocompatibility complex]]
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[[Category: t cell antigen receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:09:06 2007''
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: T-Cell Receptor]]
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[[Category: Degano M]]
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[[Category: Garcia KC]]
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[[Category: Wilson IA]]

Current revision

STRUCTURE OF THE 2C/KB/DEV8 COMPLEX

PDB ID 2ckb

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