2ch5

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{{Seed}}
 
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[[Image:2ch5.png|left|200px]]
 
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==Crystal structure of human N-acetylglucosamine kinase in complex with N-acetylglucosamine==
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The line below this paragraph, containing "STRUCTURE_2ch5", creates the "Structure Box" on the page.
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<StructureSection load='2ch5' size='340' side='right'caption='[[2ch5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ch5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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{{STRUCTURE_2ch5| PDB=2ch5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch5 OCA], [https://pdbe.org/2ch5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch5 ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN COMPLEX WITH N-ACETYLGLUCOSAMINE===
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== Function ==
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[https://www.uniprot.org/uniprot/NAGK_HUMAN NAGK_HUMAN] Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.<ref>PMID:22692205</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17010375 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch5_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17010375}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2CH5 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH5 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ch5 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:17010375</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: N-acetylglucosamine kinase]]
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[[Category: Large Structures]]
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[[Category: Berger, M.]]
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[[Category: Berger M]]
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[[Category: Chen, H.]]
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[[Category: Chen H]]
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[[Category: Hinderlich, S.]]
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[[Category: Hinderlich S]]
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[[Category: Saenger, W.]]
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[[Category: Saenger W]]
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[[Category: Weihofen, W A.]]
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[[Category: Weihofen WA]]
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[[Category: Closed conformation]]
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[[Category: Domain rotation]]
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[[Category: Glcnac]]
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[[Category: Hypothetical protein]]
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[[Category: N-acetylglucosamine]]
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[[Category: Open conformation]]
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[[Category: Ribonuclease h fold]]
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[[Category: Sugar kinase]]
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[[Category: Sugar kinase/hsp70/actin superfamily]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:43:29 2009''
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Current revision

Crystal structure of human N-acetylglucosamine kinase in complex with N-acetylglucosamine

PDB ID 2ch5

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