1qiu

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{{Seed}}
 
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[[Image:1qiu.png|left|200px]]
 
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==A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for biological fibres==
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The line below this paragraph, containing "STRUCTURE_1qiu", creates the "Structure Box" on the page.
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<StructureSection load='1qiu' size='340' side='right'caption='[[1qiu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qiu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. The December 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QIU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qiu OCA], [https://pdbe.org/1qiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qiu RCSB], [https://www.ebi.ac.uk/pdbsum/1qiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qiu ProSAT]</span></td></tr>
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{{STRUCTURE_1qiu| PDB=1qiu | SCENE= }}
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</table>
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== Function ==
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===A TRIPLE BETA-SPIRAL IN THE ADENOVIRUS FIBRE SHAFT REVEALS A NEW STRUCTURAL MOTIF FOR BIOLOGICAL FIBRES===
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[https://www.uniprot.org/uniprot/SPIKE_ADE02 SPIKE_ADE02] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell. The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction. Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins. Heparan sulfate might also play a role in virus binding.<ref>PMID:10704346</ref> <ref>PMID:12297051</ref> <ref>PMID:21843868</ref> <ref>PMID:9525681</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 10553913 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/1qiu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10553913}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qiu ConSurf].
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1QIU is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIU OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:10553913</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Adenovirus]]
[[Category: Human adenovirus 2]]
[[Category: Human adenovirus 2]]
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[[Category: Cusack, S.]]
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[[Category: Large Structures]]
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[[Category: Lavigne, G.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Mitraki, A.]]
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[[Category: Cusack S]]
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[[Category: Raaij, M J.Van.]]
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[[Category: Lavigne G]]
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[[Category: Adenovirus]]
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[[Category: Mitraki A]]
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[[Category: Fibre protein]]
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[[Category: Van Raaij MJ]]
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[[Category: Triple beta-spiral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:45:13 2009''
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Current revision

A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for biological fibres

PDB ID 1qiu

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