1gmj

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{{Seed}}
 
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[[Image:1gmj.png|left|200px]]
 
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==The structure of bovine IF1, the regulatory subunit of mitochondrial F-ATPase==
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The line below this paragraph, containing "STRUCTURE_1gmj", creates the "Structure Box" on the page.
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<StructureSection load='1gmj' size='340' side='right'caption='[[1gmj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gmj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GMJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gmj OCA], [https://pdbe.org/1gmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gmj RCSB], [https://www.ebi.ac.uk/pdbsum/1gmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gmj ProSAT]</span></td></tr>
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{{STRUCTURE_1gmj| PDB=1gmj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATIF1_BOVIN ATIF1_BOVIN] Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.<ref>PMID:7397110</ref> <ref>PMID:10831597</ref> <ref>PMID:18687699</ref> <ref>PMID:21192948</ref> <ref>PMID:12923572</ref> <ref>PMID:17895376</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gmj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gmj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In mitochondria, the hydrolytic activity of ATP synthase is regulated by an inhibitor protein, IF(1). Its binding to ATP synthase depends on pH, and below neutrality, IF(1) is dimeric and forms a stable complex with the enzyme. At higher pH values, IF(1) forms tetramers and is inactive. In the 2.2 A structure of the bovine IF(1) described here, the four monomers in the asymmetric unit are arranged as a dimer of dimers. Monomers form dimers via an antiparallel alpha-helical coiled coil in the C-terminal region. Dimers are associated into oligomers and form long fibres in the crystal lattice, via coiled-coil interactions in the N-terminal and inhibitory regions (residues 14-47). Therefore, tetramer formation masks the inhibitory region, preventing IF(1) binding to ATP synthase.
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===THE STRUCTURE OF BOVINE IF1, THE REGULATORY SUBUNIT OF MITOCHONDRIAL F-ATPASE===
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The structure of bovine IF(1), the regulatory subunit of mitochondrial F-ATPase.,Cabezon E, Runswick MJ, Leslie AG, Walker JE EMBO J. 2001 Dec 17;20(24):6990-6. PMID:11742976<ref>PMID:11742976</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11742976}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gmj" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11742976 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11742976}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GMJ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMJ OCA].
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==Reference==
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<ref group="xtra">PMID:11742976</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Cabezon, E.]]
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[[Category: Large Structures]]
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[[Category: Leslie, A G.W.]]
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[[Category: Cabezon E]]
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[[Category: Runswick, M J.]]
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[[Category: Leslie AGW]]
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[[Category: Walker, J E.]]
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[[Category: Runswick MJ]]
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[[Category: Atp hydrolysis]]
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[[Category: Walker JE]]
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[[Category: Bovine f1-atpase inhibitor protein]]
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[[Category: Coiled-coil structure]]
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[[Category: P dependent oligomerization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:58:46 2009''
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Current revision

The structure of bovine IF1, the regulatory subunit of mitochondrial F-ATPase

PDB ID 1gmj

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