2cro

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(New page: 200px<br /><applet load="2cro" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cro, resolution 2.35&Aring;" /> '''STRUCTURE OF PHAGE 4...)
Current revision (09:18, 14 February 2024) (edit) (undo)
 
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[[Image:2cro.gif|left|200px]]<br /><applet load="2cro" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cro, resolution 2.35&Aring;" />
 
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'''STRUCTURE OF PHAGE 434 CRO PROTEIN AT 2.35 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==STRUCTURE OF PHAGE 434 CRO PROTEIN AT 2.35 ANGSTROMS RESOLUTION==
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The crystal structure of phage 434 Cro protein has been determined and, refined against 2.35 A data to an R-factor of 19.5%. The protein comprises, five alpha-helices and shows the helix-turn-helix motif found in other, repressor proteins.
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<StructureSection load='2cro' size='340' side='right'caption='[[2cro]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2cro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_434 Phage 434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRO FirstGlance]. <br>
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2CRO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_434 Bacteriophage 434]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CRO OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cro OCA], [https://pdbe.org/2cro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cro RCSB], [https://www.ebi.ac.uk/pdbsum/2cro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cro ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of phage 434 Cro protein at 2.35 A resolution., Mondragon A, Wolberger C, Harrison SC, J Mol Biol. 1989 Jan 5;205(1):179-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2647998 2647998]
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== Function ==
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[[Category: Bacteriophage 434]]
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[https://www.uniprot.org/uniprot/RCRO_BP434 RCRO_BP434] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
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[[Category: Single protein]]
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== Evolutionary Conservation ==
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[[Category: Harrison, S.C.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Mondragon, A.]]
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Check<jmol>
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[[Category: Wolberger, C.]]
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<jmolCheckbox>
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[[Category: gene regulating protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cro_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:13:57 2007''
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cro ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Phage 434]]
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[[Category: Harrison SC]]
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[[Category: Mondragon A]]
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[[Category: Wolberger C]]

Current revision

STRUCTURE OF PHAGE 434 CRO PROTEIN AT 2.35 ANGSTROMS RESOLUTION

PDB ID 2cro

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