1owx

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{{Seed}}
 
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[[Image:1owx.png|left|200px]]
 
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==Solution structure of the C-terminal RRM of human La (La225-334)==
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The line below this paragraph, containing "STRUCTURE_1owx", creates the "Structure Box" on the page.
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<StructureSection load='1owx' size='340' side='right'caption='[[1owx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1owx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OWX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1owx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1owx OCA], [https://pdbe.org/1owx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1owx RCSB], [https://www.ebi.ac.uk/pdbsum/1owx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1owx ProSAT]</span></td></tr>
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{{STRUCTURE_1owx| PDB=1owx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LA_HUMAN LA_HUMAN] Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.<ref>PMID:3192525</ref> <ref>PMID:2470590</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/1owx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1owx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The La protein is an important component of ribonucleoprotein complexes that acts mainly as an RNA chaperone to facilitate correct processing and maturation of RNA polymerase III transcripts, but can also stimulate translation initiation. We report here the structure of the C-terminal domain of human La, which comprises an atypical RNA recognition motif (La225-334) and a long unstructured C-terminal tail. The central beta sheet of La225-334 reveals novel features: the putative RNA binding surface is formed by a five-stranded beta sheet and, strikingly, is largely obscured by a long C-terminal alpha helix that encompasses a recently identified nuclear retention element. Contrary to previous observations, we find that the La protein does not contain a dimerization domain.
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===Solution structure of the C-terminal RRM of human La (La225-334)===
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Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element.,Jacks A, Babon J, Kelly G, Manolaridis I, Cary PD, Curry S, Conte MR Structure. 2003 Jul;11(7):833-43. PMID:12842046<ref>PMID:12842046</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12842046}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1owx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12842046 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_12842046}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1OWX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWX OCA].
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==Reference==
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<ref group="xtra">PMID:12842046</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Babon, J.]]
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[[Category: Large Structures]]
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[[Category: Cary, P D.]]
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[[Category: Babon J]]
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[[Category: Conte, M R.]]
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[[Category: Cary PD]]
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[[Category: Curry, S.]]
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[[Category: Conte MR]]
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[[Category: Jacks, A.]]
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[[Category: Curry S]]
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[[Category: Kelly, G.]]
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[[Category: Jacks A]]
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[[Category: Manolaridis, I.]]
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[[Category: Kelly G]]
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[[Category: Rrm]]
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[[Category: Manolaridis I]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:08:10 2009''
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Current revision

Solution structure of the C-terminal RRM of human La (La225-334)

PDB ID 1owx

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OCA

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