1hth

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:35, 27 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1hth.png|left|200px]]
 
-
<!--
+
==The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures==
-
The line below this paragraph, containing "STRUCTURE_1hth", creates the "Structure Box" on the page.
+
<StructureSection load='1hth' size='340' side='right'caption='[[1hth]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1hth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
-
{{STRUCTURE_1hth| PDB=1hth | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hth OCA], [https://pdbe.org/1hth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hth RCSB], [https://www.ebi.ac.uk/pdbsum/1hth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hth ProSAT]</span></td></tr>
-
 
+
</table>
-
===THE SOLUTION STRUCTURE OF CYCLIC HUMAN PARATHYROID HORMONE FRAGMENT 1-34, NMR, 10 STRUCTURES===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>
-
 
+
== Function ==
-
<!--
+
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10050767}}, adds the Publication Abstract to the page
+
== Evolutionary Conservation ==
-
(as it appears on PubMed at http://www.pubmed.gov), where 10050767 is the PubMed ID number.
+
[[Image:Consurf_key_small.gif|200px|right]]
-
-->
+
Check<jmol>
-
{{ABSTRACT_PUBMED_10050767}}
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/1hth_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
1HTH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTH OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==Reference==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hth ConSurf].
-
<ref group="xtra">PMID:10050767</ref><references group="xtra"/>
+
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Esswein, A.]]
+
[[Category: Large Structures]]
-
[[Category: Hofmann, E.]]
+
[[Category: Esswein A]]
-
[[Category: Roesch, P.]]
+
[[Category: Hofmann E]]
-
[[Category: Schaefer, W.]]
+
[[Category: Roesch P]]
-
[[Category: Seidel, G.]]
+
[[Category: Schaefer W]]
-
[[Category: Cyclic]]
+
[[Category: Seidel G]]
-
[[Category: Human parathyroid hormone]]
+
-
[[Category: Nmr structure]]
+
-
[[Category: Norleucine]]
+
-
[[Category: Ornithine]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:13:42 2009''
+

Current revision

The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures

PDB ID 1hth

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hth"
Personal tools