1y7q

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{{Seed}}
 
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[[Image:1y7q.png|left|200px]]
 
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==Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain==
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The line below this paragraph, containing "STRUCTURE_1y7q", creates the "Structure Box" on the page.
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<StructureSection load='1y7q' size='340' side='right'caption='[[1y7q]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1y7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7q OCA], [https://pdbe.org/1y7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7q RCSB], [https://www.ebi.ac.uk/pdbsum/1y7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7q ProSAT]</span></td></tr>
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{{STRUCTURE_1y7q| PDB=1y7q | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZN174_HUMAN ZN174_HUMAN] Transcriptional repressor.<ref>PMID:7673192</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Retroviral assembly is driven by multiple interactions mediated by the Gag polyprotein, the main structural component of the forming viral shell. Critical determinants of Gag oligomerization are contained within the C-terminal domain (CTD) of the capsid protein, which also harbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable Gag. An unexpected clue about the MHR function in retroviral assembly emerges from the structure of the zinc finger-associated SCAN domain we describe here. The SCAN dimer adopts a fold almost identical to that of the retroviral capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like element between the monomers. Mutations in retroviral capsid proteins and functional data suggest that a SCAN-like MHR-swapped CTD dimer forms during immature particle assembly. In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance.
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===Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain===
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Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.,Ivanov D, Stone JR, Maki JL, Collins T, Wagner G Mol Cell. 2005 Jan 7;17(1):137-43. PMID:15629724<ref>PMID:15629724</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15629724}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1y7q" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15629724 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15629724}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Y7Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].
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==Reference==
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<ref group="xtra">PMID:15629724</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Collins, T.]]
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[[Category: Large Structures]]
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[[Category: Ivanov, D.]]
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[[Category: Collins T]]
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[[Category: Maki, J L.]]
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[[Category: Ivanov D]]
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[[Category: Stone, J R.]]
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[[Category: Maki JL]]
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[[Category: Wagner, G.]]
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[[Category: Stone JR]]
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[[Category: C2h2 zinc finger associated]]
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[[Category: Wagner G]]
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[[Category: Dimer]]
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[[Category: Retroviral capsid c-terminal domain]]
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[[Category: Scan domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:26:31 2009''
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Current revision

Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain

PDB ID 1y7q

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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