We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2if9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:11, 6 November 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2if9.png|left|200px]]
 
-
<!--
+
==Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer==
-
The line below this paragraph, containing "STRUCTURE_2if9", creates the "Structure Box" on the page.
+
<StructureSection load='2if9' size='340' side='right'caption='[[2if9]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2if9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta_polyomavirus_1 Macaca mulatta polyomavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.586&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if9 OCA], [https://pdbe.org/2if9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if9 RCSB], [https://www.ebi.ac.uk/pdbsum/2if9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if9 ProSAT]</span></td></tr>
-
{{STRUCTURE_2if9| PDB=2if9 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q98ZP7_SV40 Q98ZP7_SV40]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2if9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2if9 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
DNA replication is initiated upon binding of "initiators" to origins of replication. In simian virus 40 (SV40), the core origin contains four pentanucleotide binding sites organized as pairs of inverted repeats. Here we describe the crystal structures of the origin binding domain (obd) of the SV40 large T-antigen (T-ag) both with and without a subfragment of origin-containing DNA. In the co-structure, two T-ag obds are oriented in a head-to-head fashion on the same face of the DNA, and each T-ag obd engages the major groove. Although the obds are very close to each other when bound to this DNA target, they do not contact one another. These data provide a high-resolution structural model that explains site-specific binding to the origin and suggests how these interactions help direct the oligomerization events that culminate in assembly of the helicase-active dodecameric complex of T-ag.
-
===Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer===
+
The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA.,Meinke G, Phelan P, Moine S, Bochkareva E, Bochkarev A, Bullock PA, Bohm A PLoS Biol. 2007 Feb;5(2):e23. PMID:17253903<ref>PMID:17253903</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2if9" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_17253903}}, adds the Publication Abstract to the page
+
*[[Large T Antigen|Large T Antigen]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 17253903 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17253903}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2IF9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF9 OCA].
+
[[Category: Macaca mulatta polyomavirus 1]]
-
 
+
[[Category: Bohm A]]
-
==Reference==
+
[[Category: Bullock PA]]
-
<ref group="xtra">PMID:17253903</ref><references group="xtra"/>
+
[[Category: Meinke G]]
-
[[Category: Simian virus 40]]
+
-
[[Category: Bohm, A.]]
+
-
[[Category: Bullock, P A.]]
+
-
[[Category: Meinke, G.]]
+
-
[[Category: Origin binding domain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:26:42 2009''
+

Current revision

Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer

PDB ID 2if9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2if9"
Personal tools