1poz

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{{Seed}}
 
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[[Image:1poz.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44==
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The line below this paragraph, containing "STRUCTURE_1poz", creates the "Structure Box" on the page.
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<StructureSection load='1poz' size='340' side='right'caption='[[1poz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1poz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1poz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1poz OCA], [https://pdbe.org/1poz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1poz RCSB], [https://www.ebi.ac.uk/pdbsum/1poz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1poz ProSAT]</span></td></tr>
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{{STRUCTURE_1poz| PDB=1poz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/1poz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1poz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding domain and a formerly unidentified protein fold. Moreover, the disposition of key N-glycosylation sites reveals how specific sugar chains could alter both the affinity and avidity of CD44 HA binding. Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies.
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===SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44===
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Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.,Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG Mol Cell. 2004 Feb 27;13(4):483-96. PMID:14992719<ref>PMID:14992719</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1poz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14992719}}, adds the Publication Abstract to the page
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*[[CD44|CD44]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14992719 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14992719}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1POZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA].
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==Reference==
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<ref group="xtra">PMID:14992719</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banerji, S.]]
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[[Category: Large Structures]]
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[[Category: Blundell, C D.]]
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[[Category: Banerji S]]
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[[Category: Campbell, I D.]]
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[[Category: Blundell CD]]
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[[Category: Day, A J.]]
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[[Category: Campbell ID]]
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[[Category: Jackson, D G.]]
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[[Category: Day AJ]]
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[[Category: Kahmann, J D.]]
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[[Category: Jackson DG]]
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[[Category: Pickford, A R.]]
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[[Category: Kahmann JD]]
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[[Category: Teriete, P.]]
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[[Category: Pickford AR]]
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[[Category: Wright, A J.]]
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[[Category: Teriete P]]
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[[Category: Carbohydrate-binding domain]]
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[[Category: Wright AJ]]
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[[Category: Cell adhesion]]
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[[Category: Glycoprotein]]
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[[Category: Hyaluronan-binding domain]]
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[[Category: Link module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:27:51 2009''
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Current revision

SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44

PDB ID 1poz

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