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1t61

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{{Seed}}
 
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[[Image:1t61.png|left|200px]]
 
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==crystal structure of collagen IV NC1 domain from placenta basement membrane==
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The line below this paragraph, containing "STRUCTURE_1t61", creates the "Structure Box" on the page.
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<StructureSection load='1t61' size='340' side='right'caption='[[1t61]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t61]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T61 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_1t61| PDB=1t61 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t61 OCA], [https://pdbe.org/1t61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t61 RCSB], [https://www.ebi.ac.uk/pdbsum/1t61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t61 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CO4A1_BOVIN CO4A1_BOVIN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.[UniProtKB:P02463] Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.[UniProtKB:P02462]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t61_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t61 ConSurf].
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<div style="clear:both"></div>
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===crystal structure of collagen IV NC1 domain from placenta basement membrane===
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==See Also==
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*[[Collagen 3D structures|Collagen 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15299013}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15299013 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299013}}
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==About this Structure==
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1T61 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T61 OCA].
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==Reference==
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<ref group="xtra">PMID:15299013</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Bondar, O.]]
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[[Category: Large Structures]]
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[[Category: Friedman, D B.]]
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[[Category: Bondar O]]
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[[Category: Hudson, B G.]]
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[[Category: Friedman DB]]
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[[Category: Shanmugasundararaj, S.]]
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[[Category: Hudson BG]]
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[[Category: Sundaramoorthy, M.]]
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[[Category: Shanmugasundararaj S]]
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[[Category: Vanacore, R M.]]
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[[Category: Sundaramoorthy M]]
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[[Category: Basement membrane]]
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[[Category: Vanacore RM]]
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[[Category: Nc1 domain]]
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[[Category: Type iv collagen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:28:56 2009''
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Current revision

crystal structure of collagen IV NC1 domain from placenta basement membrane

PDB ID 1t61

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