1wwr

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{{Seed}}
 
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[[Image:1wwr.png|left|200px]]
 
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==Crystal structure of tRNA adenosine deaminase TadA from Aquifex aeolicus==
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The line below this paragraph, containing "STRUCTURE_1wwr", creates the "Structure Box" on the page.
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<StructureSection load='1wwr' size='340' side='right'caption='[[1wwr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wwr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WWR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1wwr| PDB=1wwr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwr OCA], [https://pdbe.org/1wwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wwr RCSB], [https://www.ebi.ac.uk/pdbsum/1wwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wwr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wwr TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TADA_AQUAE TADA_AQUAE] Deaminates adenosine-34 to inosine in tRNA-Arg2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1wwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wwr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bacterial tRNA adenosine deaminase (TadA) generates inosine by deaminating the adenosine residue at the wobble position of tRNA(Arg-2). This modification is essential for the decoding system. In this study, we determined the crystal structure of Aquifex aeolicus TadA at a 1.8-A resolution. This is the first structure of a deaminase acting on tRNA. A. aeolicus TadA has an alpha/beta/alpha three-layered fold and forms a homodimer. The A. aeolicus TadA dimeric structure is completely different from the tetrameric structure of yeast CDD1, which deaminates mRNA and cytidine, but is similar to the dimeric structure of yeast cytosine deaminase. However, in the A. aeolicus TadA structure, the shapes of the C-terminal helix and the regions between the beta4 and beta5 strands are quite distinct from those of yeast cytosine deaminase and a large cavity is produced. This cavity contains many conserved amino acid residues that are likely to be involved in either catalysis or tRNA binding. We made a docking model of TadA with the tRNA anticodon stem loop.
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===Crystal structure of tRNA adenosine deaminase TadA from Aquifex aeolicus===
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Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus.,Kuratani M, Ishii R, Bessho Y, Fukunaga R, Sengoku T, Shirouzu M, Sekine S, Yokoyama S J Biol Chem. 2005 Apr 22;280(16):16002-8. Epub 2005 Jan 26. PMID:15677468<ref>PMID:15677468</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wwr" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15677468}}, adds the Publication Abstract to the page
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*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15677468 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15677468}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1WWR is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWR OCA].
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==Reference==
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<ref group="xtra">PMID:15677468</ref><references group="xtra"/>
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[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Bessho, Y.]]
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[[Category: Large Structures]]
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[[Category: Fukunaga, R.]]
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[[Category: Bessho Y]]
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[[Category: Ishii, R.]]
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[[Category: Fukunaga R]]
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[[Category: Kuratani, M.]]
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[[Category: Ishii R]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Kuratani M]]
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[[Category: Sekine, S.]]
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[[Category: Sekine S]]
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[[Category: Sengoku, T.]]
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[[Category: Sengoku T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Homodimer]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:31:41 2009''
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Current revision

Crystal structure of tRNA adenosine deaminase TadA from Aquifex aeolicus

PDB ID 1wwr

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