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1ms6

From Proteopedia

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{{Seed}}
 
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[[Image:1ms6.png|left|200px]]
 
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<!--
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==Dipeptide Nitrile Inhibitor Bound to Cathepsin S.==
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The line below this paragraph, containing "STRUCTURE_1ms6", creates the "Structure Box" on the page.
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<StructureSection load='1ms6' size='340' side='right'caption='[[1ms6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene></td></tr>
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{{STRUCTURE_1ms6| PDB=1ms6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [https://pdbe.org/1ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms6 ConSurf].
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<div style="clear:both"></div>
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===Dipeptide Nitrile Inhibitor Bound to Cathepsin S.===
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12459015}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12459015 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_12459015}}
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==About this Structure==
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1MS6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA].
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==Reference==
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<ref group="xtra">PMID:12459015</ref><references group="xtra"/>
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bekkali, Y.]]
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[[Category: Large Structures]]
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[[Category: Brown, M L.]]
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[[Category: Bekkali Y]]
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[[Category: Crane, K.]]
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[[Category: Brown ML]]
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[[Category: Cywin, C L.]]
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[[Category: Crane K]]
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[[Category: Davidson, W.]]
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[[Category: Cywin CL]]
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[[Category: DeTuri, M.]]
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[[Category: Davidson W]]
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[[Category: Emmanuel, M J.]]
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[[Category: DeTuri M]]
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[[Category: Freeman, D M.]]
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[[Category: Emmanuel MJ]]
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[[Category: Frye, L L.]]
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[[Category: Freeman DM]]
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[[Category: Giradot, M.]]
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[[Category: Frye LL]]
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[[Category: Grygon, C A.]]
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[[Category: Giradot M]]
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[[Category: Hao, M H.]]
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[[Category: Grygon CA]]
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[[Category: Hopkins, J L.]]
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[[Category: Hao MH]]
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[[Category: Hrapchak, M.]]
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[[Category: Hopkins JL]]
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[[Category: Labadia, M E.]]
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[[Category: Hrapchak M]]
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[[Category: McNeil, D.]]
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[[Category: Labadia ME]]
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[[Category: Morwick, T.]]
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[[Category: McNeil D]]
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[[Category: Pav, S.]]
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[[Category: Morwick T]]
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[[Category: Spero, D M.]]
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[[Category: Pav S]]
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[[Category: Thomson, D S.]]
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[[Category: Spero DM]]
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[[Category: Wang, Y.]]
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[[Category: Thomson DS]]
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[[Category: Ward, Y D.]]
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[[Category: Wang Y]]
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[[Category: White, D.]]
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[[Category: Ward YD]]
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[[Category: Zindell, R.]]
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[[Category: White D]]
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[[Category: Cathepsin]]
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[[Category: Zindell R]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:34:14 2009''
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Current revision

Dipeptide Nitrile Inhibitor Bound to Cathepsin S.

PDB ID 1ms6

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