1yon

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{{Seed}}
 
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[[Image:1yon.png|left|200px]]
 
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==Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate==
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The line below this paragraph, containing "STRUCTURE_1yon", creates the "Structure Box" on the page.
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<StructureSection load='1yon' size='340' side='right'caption='[[1yon]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YON FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2R:[(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>A2R</scene></td></tr>
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{{STRUCTURE_1yon| PDB=1yon | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yon OCA], [https://pdbe.org/1yon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yon RCSB], [https://www.ebi.ac.uk/pdbsum/1yon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yon ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PANE_ECOLI PANE_ECOLI] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yo/1yon_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yon ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of Escherichia coli ketopantoate reductase in complex with 2'-monophosphoadenosine 5'-diphosphoribose, a fragment of NADP+ that lacks the nicotinamide ring, is reported. The ligand is bound at the enzyme active site in the opposite orientation to that observed for NADP+, with the adenine ring occupying the lipophilic nicotinamide pocket. Isothermal titration calorimetry with R31A and N98A mutants of the enzyme is used to show that the unusual ;reversed binding mode' observed in the crystal is triggered by changes in the protonation of binding groups at low pH. This research has important implications for fragment-based approaches to drug design, namely that the crystallization conditions and the chemical modification of ligands can have unexpected effects on the binding modes.
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===Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate===
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pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.,Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):171-8. Epub 2007, Jan 16. PMID:17242510<ref>PMID:17242510</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17242510}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1yon" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17242510 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17242510}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1YON is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YON OCA].
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==Reference==
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<ref group="xtra">PMID:17242510</ref><references group="xtra"/>
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[[Category: 2-dehydropantoate 2-reductase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Abell, C.]]
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[[Category: Large Structures]]
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[[Category: Blundell, T L.]]
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[[Category: Abell C]]
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[[Category: Ciulli, A.]]
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[[Category: Blundell TL]]
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[[Category: Lobley, C M.C.]]
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[[Category: Ciulli A]]
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[[Category: Smith, A G.]]
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[[Category: Lobley CMC]]
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[[Category: Tuck, K L.]]
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[[Category: Smith AG]]
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[[Category: Williams, G.]]
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[[Category: Tuck KL]]
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[[Category: 2'-monophosphoadenosine-5'-diphosphate]]
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[[Category: Williams G]]
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[[Category: Ketopantoate]]
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[[Category: Nadp+ dependent]]
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[[Category: Pantothenate pathway]]
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[[Category: Secondary alcohol dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:40:53 2009''
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Current revision

Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate

PDB ID 1yon

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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