1zms

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:05, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1zms.png|left|200px]]
 
-
<!--
+
==LMP1 Protein binds to TRAF3 as a structural CD40==
-
The line below this paragraph, containing "STRUCTURE_1zms", creates the "Structure Box" on the page.
+
<StructureSection load='1zms' size='340' side='right'caption='[[1zms]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1zms]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_RAJI Human herpesvirus 4 strain RAJI]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZMS FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zms OCA], [https://pdbe.org/1zms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zms RCSB], [https://www.ebi.ac.uk/pdbsum/1zms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zms ProSAT]</span></td></tr>
-
{{STRUCTURE_1zms| PDB=1zms | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[https://omim.org/entry/614849 614849]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref> <ref>PMID:15084608</ref> <ref>PMID:17991829</ref> <ref>PMID:20097753</ref> <ref>PMID:20185819</ref> <ref>PMID:19937093</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zm/1zms_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zms ConSurf].
 +
<div style="clear:both"></div>
-
===LMP1 Protein binds to TRAF3 as a structural CD40===
+
==See Also==
-
 
+
*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16009714}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16009714 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_16009714}}
+
-
 
+
-
==About this Structure==
+
-
1ZMS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMS OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16009714</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bishop, G A.]]
+
[[Category: Human herpesvirus 4 strain RAJI]]
-
[[Category: Ely, K R.]]
+
[[Category: Large Structures]]
-
[[Category: Li, C.]]
+
[[Category: Bishop GA]]
-
[[Category: Ni, C Z.]]
+
[[Category: Ely KR]]
-
[[Category: Reed, J C.]]
+
[[Category: Li C]]
-
[[Category: Satterthwait, A C.]]
+
[[Category: Ni C-Z]]
-
[[Category: Welsh, K.]]
+
[[Category: Reed JC]]
-
[[Category: Wu, S D.]]
+
[[Category: Satterthwait AC]]
-
[[Category: Xie, P.]]
+
[[Category: Welsh K]]
-
[[Category: Zhu, X.]]
+
[[Category: Wu SD]]
-
[[Category: Cd40]]
+
[[Category: Xie P]]
-
[[Category: Lmp1]]
+
[[Category: Zhu X]]
-
[[Category: Nf-kb signaling]]
+
-
[[Category: Tnf receptor]]
+
-
[[Category: Traf3]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:54:13 2009''
+

Current revision

LMP1 Protein binds to TRAF3 as a structural CD40

PDB ID 1zms

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zms"
Personal tools