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2cz2
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2cz2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cz2, resolution 1.40Å" /> '''Crystal structure of...) |
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| - | [[Image:2cz2.gif|left|200px]]<br /><applet load="2cz2" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2cz2, resolution 1.40Å" /> | ||
| - | '''Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)'''<br /> | ||
| - | == | + | ==Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)== |
| - | + | <StructureSection load='2cz2' size='340' side='right'caption='[[2cz2]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2cz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ2 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz2 OCA], [https://pdbe.org/2cz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz2 TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/MAAI_MOUSE MAAI_MOUSE] Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity). |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz2_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz2 ConSurf]. |
| - | [ | + | <div style="clear:both"></div> |
| - | [[ | + | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Kinoshita Y]] | ||
| + | [[Category: Mizohata E]] | ||
| + | [[Category: Morita S]] | ||
| + | [[Category: Nagano K]] | ||
| + | [[Category: Shirouzu M]] | ||
| + | [[Category: Uchikubo T]] | ||
| + | [[Category: Uda H]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from Mus musculus (form-1 crystal)
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Categories: Large Structures | Mus musculus | Kinoshita Y | Mizohata E | Morita S | Nagano K | Shirouzu M | Uchikubo T | Uda H | Yokoyama S
