2cze

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(New page: 200px<br /><applet load="2cze" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cze, resolution 1.85&Aring;" /> '''Crystal structure of...)
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[[Image:2cze.gif|left|200px]]<br /><applet load="2cze" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cze, resolution 1.85&Aring;" />
 
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'''Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP'''<br />
 
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==About this Structure==
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==Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP==
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2CZE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with U5P, CIT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CZE OCA].
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<StructureSection load='2cze' size='340' side='right'caption='[[2cze]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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== Structural highlights ==
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[[Category: Pyrococcus horikoshii]]
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<table><tr><td colspan='2'>[[2cze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZE FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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[[Category: Arai, R.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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[[Category: Ito, K.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cze OCA], [https://pdbe.org/2cze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cze RCSB], [https://www.ebi.ac.uk/pdbsum/2cze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cze ProSAT], [https://www.topsan.org/Proteins/RSGI/2cze TOPSAN]</span></td></tr>
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[[Category: Kishishita, S.]]
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</table>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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== Function ==
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[[Category: Shirouzu, M.]]
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[https://www.uniprot.org/uniprot/PYRF_PYRHO PYRF_PYRHO] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity).[HAMAP-Rule:MF_01200_A]
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[[Category: Yokoyama, S.]]
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== Evolutionary Conservation ==
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[[Category: CIT]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: GOL]]
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Check<jmol>
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[[Category: U5P]]
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<jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cze_consurf.spt"</scriptWhenChecked>
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[[Category: nppsfa]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: orotidine 5'-phosphate decarboxylase (ompdecase)]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: pyrimidine biosynthesis]]
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</jmolCheckbox>
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[[Category: riken structural genomics/proteomics initiative]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cze ConSurf].
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[[Category: rsgi]]
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<div style="clear:both"></div>
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[[Category: structural genomics]]
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[[Category: ump]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:21:50 2007''
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==See Also==
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Arai R]]
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[[Category: Ito K]]
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[[Category: Kishishita S]]
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[[Category: Shirouzu M]]
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[[Category: Yokoyama S]]

Current revision

Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 complexed with UMP

PDB ID 2cze

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