1p7n

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{{Seed}}
 
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[[Image:1p7n.png|left|200px]]
 
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==Dimeric Rous Sarcoma virus Capsid protein structure with an upstream 25-amino acid residue extension of C-terminal of Gag p10 protein==
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The line below this paragraph, containing "STRUCTURE_1p7n", creates the "Structure Box" on the page.
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<StructureSection load='1p7n' size='340' side='right'caption='[[1p7n]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P7N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7n OCA], [https://pdbe.org/1p7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p7n RCSB], [https://www.ebi.ac.uk/pdbsum/1p7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p7n ProSAT]</span></td></tr>
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{{STRUCTURE_1p7n| PDB=1p7n | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p7n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the N-terminal domain (NTD) of Rous sarcoma virus (RSV) capsid protein (CA), with an upstream 25 amino acid residue extension corresponding to the C-terminal portion of the Gag p10 protein, has been determined by X-ray crystallography. Purified Gag proteins of retroviruses can assemble in vitro into virus-like particles closely resembling in vivo-assembled immature virus particles, but without a membrane. When the 25 amino acid residues upstream of CA are deleted, Gag assembles into tubular particles. The same phenotype is observed in vivo. Thus, these residues act as a "shape determinant" promoting spherical assembly, when they are present, or tubular assembly, when they are absent. We show that, unlike the NTD on its own, the extended NTD protein has no beta-hairpin loop at the N terminus of CA and that the molecule forms a dimer in which the amino-terminal extension forms the interface between monomers. Since dimerization of Gag has been inferred to be a critical step in assembly of spherical, immature Gag particles, the dimer interface may represent a structural feature that is essential in retrovirus assembly.
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===Dimeric Rous Sarcoma virus Capsid protein structure with an upstream 25-amino acid residue extension of C-terminal of Gag p10 protein===
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Dimeric rous sarcoma virus capsid protein structure relevant to immature Gag assembly.,Nandhagopal N, Simpson AA, Johnson MC, Francisco AB, Schatz GW, Rossmann MG, Vogt VM J Mol Biol. 2004 Jan 2;335(1):275-82. PMID:14659756<ref>PMID:14659756</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1p7n" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14659756}}, adds the Publication Abstract to the page
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14659756 is the PubMed ID number.
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_14659756}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1P7N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P7N OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:14659756</ref><references group="xtra"/>
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[[Category: Rous sarcoma virus]]
[[Category: Rous sarcoma virus]]
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[[Category: Francisco, A B.]]
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[[Category: Francisco AB]]
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[[Category: Johnson, M C.]]
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[[Category: Johnson MC]]
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[[Category: Nandhagopal, N.]]
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[[Category: Nandhagopal N]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann MG]]
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[[Category: Schatz, G W.]]
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[[Category: Schatz GW]]
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[[Category: Simpson, A A.]]
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[[Category: Simpson AA]]
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[[Category: Vogt, V M.]]
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[[Category: Vogt VM]]
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[[Category: Capsid protein]]
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[[Category: Gag polyprotein]]
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[[Category: Immature gag]]
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[[Category: Retrovirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:06:36 2009''
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Current revision

Dimeric Rous Sarcoma virus Capsid protein structure with an upstream 25-amino acid residue extension of C-terminal of Gag p10 protein

PDB ID 1p7n

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