2v6l

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{{Seed}}
 
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[[Image:2v6l.png|left|200px]]
 
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==Molecular Model of a Type III Secretion System Needle==
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The line below this paragraph, containing "STRUCTURE_2v6l", creates the "Structure Box" on the page.
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<SX load='2v6l' size='340' side='right' viewer='molstar' caption='[[2v6l]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v6l]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6l OCA], [https://pdbe.org/2v6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6l RCSB], [https://www.ebi.ac.uk/pdbsum/2v6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6l ProSAT]</span></td></tr>
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{{STRUCTURE_2v6l| PDB=2v6l | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL] Necessary for the secretion of IPA invasins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v6l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v6l ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens. The type III secretion system consists of cytoplasmic, transmembrane, and extracellular domains. The extracellular domain is a hollow needle protruding above the bacterial surface and is held within a basal body that traverses both bacterial membranes. Effector proteins are translocated, via this external needle, directly into host cells, where they subvert normal cell functions to aid infection. Physical contact with host cells initiates secretion and leads to formation of a pore, thought to be contiguous with the needle channel, in the host-cell membrane. Here, we report the crystal structure of the Shigella flexneri needle subunit MxiH and a complete model for the needle assembly built into our three-dimensional EM reconstruction. The model, combined with mutagenesis data, reveals that signaling of host-cell contact is relayed through the needle via intersubunit contacts and suggests a mode of binding for a tip complex.
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===MOLECULAR MODEL OF A TYPE III SECRETION SYSTEM NEEDLE===
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Molecular model of a type III secretion system needle: Implications for host-cell sensing.,Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12529-33. Epub 2006 Aug 3. PMID:16888041<ref>PMID:16888041</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16888041}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2v6l" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16888041 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16888041}}
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__TOC__
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</SX>
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==About this Structure==
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[[Category: Large Structures]]
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2V6L is a 28 chains structure of sequences from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6L OCA].
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==Reference==
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<ref group="xtra">PMID:16888041</ref><ref group="xtra">PMID:12571230</ref><references group="xtra"/>
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[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Blocker, A J.]]
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[[Category: Blocker AJ]]
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[[Category: Booy, F.]]
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[[Category: Booy F]]
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[[Category: Cordes, F S.]]
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[[Category: Cordes FS]]
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[[Category: Daniell, S.]]
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[[Category: Daniell S]]
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[[Category: Deane, J E.]]
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[[Category: Deane JE]]
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[[Category: Johnson, S.]]
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[[Category: Johnson S]]
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[[Category: Kenjale, R.]]
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[[Category: Kenjale R]]
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[[Category: Lea, S M.]]
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[[Category: Lea SM]]
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[[Category: Picking, W D.]]
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[[Category: Picking WD]]
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[[Category: Picking, W L.]]
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[[Category: Picking WL]]
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[[Category: Roversi, P.]]
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[[Category: Roversi P]]
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[[Category: Mxih]]
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[[Category: Needle]]
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[[Category: Plasmid]]
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[[Category: Protein transport]]
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[[Category: Shigella flexneri]]
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[[Category: T3ss]]
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[[Category: Transport]]
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[[Category: Type iii secretion system]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:10:11 2009''
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Current revision

Molecular Model of a Type III Secretion System Needle

2v6l, resolution 16.00Å

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OCA

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