1uzi

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{{Seed}}
 
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[[Image:1uzi.png|left|200px]]
 
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==C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM==
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The line below this paragraph, containing "STRUCTURE_1uzi", creates the "Structure Box" on the page.
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<StructureSection load='1uzi' size='340' side='right'caption='[[1uzi]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=V4O:CYCLO-TETRAMETAVANADATE'>V4O</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
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{{STRUCTURE_1uzi| PDB=1uzi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uzi OCA], [https://pdbe.org/1uzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uzi RCSB], [https://www.ebi.ac.uk/pdbsum/1uzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uzi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uzi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uzi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C3 exoenzyme from Clostridium botulinum (C3bot1) ADP-ribosylates and thereby inactivates Rho A, B and C GTPases in mammalian cells. The structure of a tetragonal crystal form has been determined by molecular replacement and refined to 1.89 A resolution. It is very similar to the apo structures determined previously from two different monoclinic crystal forms. An objective reassessment of available apo and nucleotide-bound C3bot1 structures indicates that, contrary to a previous report, the protein possesses a rigid core formed largely of beta-strands and that the general flexure that accompanies NAD binding is concentrated in two peripheral lobes. Tetragonal crystals disintegrate in the presence of NAD, most likely because of disruption of essential crystal contacts.
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===C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM===
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C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure.,Evans HR, Holloway DE, Sutton JM, Ayriss J, Shone CC, Acharya KR Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1502-5. Epub 2004, Jul 21. PMID:15272191<ref>PMID:15272191</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1uzi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15272191}}, adds the Publication Abstract to the page
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*[[Exoenzyme 3D structures|Exoenzyme 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15272191 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15272191}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1UZI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZI OCA].
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==Reference==
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<ref group="xtra">PMID:15272191</ref><references group="xtra"/>
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Acharya, K R.]]
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[[Category: Large Structures]]
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[[Category: Ayriss, J.]]
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[[Category: Acharya KR]]
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[[Category: Evans, H R.]]
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[[Category: Ayriss J]]
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[[Category: Holloway, D E.]]
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[[Category: Evans HR]]
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[[Category: Shone, C C.]]
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[[Category: Holloway DE]]
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[[Category: Sutton, J M.]]
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[[Category: Shone CC]]
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[[Category: Adp-ribosyltransferase]]
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[[Category: Sutton JM]]
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[[Category: C3]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:16:04 2009''
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Current revision

C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM

PDB ID 1uzi

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