1t1v

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{{Seed}}
 
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[[Image:1t1v.png|left|200px]]
 
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==Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution==
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The line below this paragraph, containing "STRUCTURE_1t1v", creates the "Structure Box" on the page.
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<StructureSection load='1t1v' size='340' side='right'caption='[[1t1v]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1t1v| PDB=1t1v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1v OCA], [https://pdbe.org/1t1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1v RCSB], [https://www.ebi.ac.uk/pdbsum/1t1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SH3L3_MOUSE SH3L3_MOUSE] Could act as a modulator of glutaredoxin biological activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the 1.6 Angstrom resolution crystal structure of SH3BGRL3, a member of a new mammalian protein family of unknown function. The observed "thioredoxin fold" of SH3BGRL3 matches the tertiary structure of glutaredoxins, even in the N-terminal region where the sequence similarity between the two protein families is negligible. In particular, SH3BGRL3 displays structural modifications at the N-terminal Cys-x-x-Cys loop, responsible for glutathione binding and catalysis in glutaredoxins. The loop hosts a six residue insertion, yielding an extra N-terminal-capped helical turn, first observed here for the thioredoxin fold. This, together with deletion of both Cys residues, results in a substantial reshaping of the neighboring cleft, where glutathione is hosted in glutaredoxins. While not active in redox reaction and glutathione binding, SH3BGRL3 may act as an endogenous modulator of glutaredoxin activities by competing, with its fully conserved thioredoxin fold, for binding to yet unknown target proteins.
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===Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution===
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Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution.,Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:15120624<ref>PMID:15120624</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15120624}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1t1v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15120624 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15120624}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1T1V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1V OCA].
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==Reference==
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<ref group="xtra">PMID:15120624</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Donadini, A.]]
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[[Category: Donadini A]]
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[[Category: Maffei, M.]]
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[[Category: Maffei M]]
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[[Category: Massaro, M.]]
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[[Category: Massaro M]]
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[[Category: Mazzocco, M.]]
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[[Category: Mazzocco M]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Scartezzini, M.]]
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[[Category: Scartezzini M]]
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[[Category: Vergano, A.]]
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[[Category: Vergano A]]
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[[Category: Glutaredoxin]]
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[[Category: Protein 3d-structure]]
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[[Category: Thioredoxin fold]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:25:10 2009''
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Current revision

Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution

PDB ID 1t1v

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