1zzv

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{{Seed}}
 
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[[Image:1zzv.png|left|200px]]
 
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==Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter FecA from Escherichia coli.==
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The line below this paragraph, containing "STRUCTURE_1zzv", creates the "Structure Box" on the page.
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<StructureSection load='1zzv' size='340' side='right'caption='[[1zzv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zzv OCA], [https://pdbe.org/1zzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zzv RCSB], [https://www.ebi.ac.uk/pdbsum/1zzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zzv ProSAT]</span></td></tr>
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{{STRUCTURE_1zzv| PDB=1zzv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FECA_ECOLI FECA_ECOLI] FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zzv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transcription of the ferric citrate import system is regulated by ferric citrate binding to the outer membrane transporter FecA. A signal indicating transporter occupancy is relayed across the outer membrane to energy-transducing and regulatory proteins embedded in the cytoplasmic membrane. Because transcriptional activation is not coupled to ferric citrate import, an allosteric mechanism underlies this complex signaling mechanism. Using evolution-based statistical analysis we have identified a sparse but structurally connected network of residues that links distant functional sites in FecA. Functional analyses of these positions confirm their involvement in the mechanism that regulates transcriptional activation in response to ferric citrate binding at the cell surface. This mechanism appears to be conserved and provides the structural basis for the allosteric signaling of TonB-dependent transporters.
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===Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter FecA from Escherichia coli.===
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Signal transduction pathway of TonB-dependent transporters.,Ferguson AD, Amezcua CA, Halabi NM, Chelliah Y, Rosen MK, Ranganathan R, Deisenhofer J Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):513-8. Epub 2006 Dec 29. PMID:17197416<ref>PMID:17197416</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17197416}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zzv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17197416 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17197416}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZZV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZV OCA].
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==Reference==
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<ref group="xtra">PMID:17197416</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Amezcua, C A.]]
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[[Category: Large Structures]]
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[[Category: Chelliah, Y.]]
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[[Category: Amezcua CA]]
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[[Category: Deisenhofer, J.]]
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[[Category: Chelliah Y]]
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[[Category: Ferguson, A D.]]
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[[Category: Deisenhofer J]]
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[[Category: Rosen, M K.]]
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[[Category: Ferguson AD]]
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[[Category: Membrane protein]]
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[[Category: Rosen MK]]
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[[Category: Metal transport]]
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[[Category: Protein nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:27:35 2009''
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Current revision

Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter FecA from Escherichia coli.

PDB ID 1zzv

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