1ztu

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{{Seed}}
 
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[[Image:1ztu.png|left|200px]]
 
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==Structure of the chromophore binding domain of bacterial phytochrome==
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The line below this paragraph, containing "STRUCTURE_1ztu", creates the "Structure Box" on the page.
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<StructureSection load='1ztu' size='340' side='right'caption='[[1ztu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ztu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLA:BILIVERDINE+IX+ALPHA'>BLA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1ztu| PDB=1ztu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ztu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ztu OCA], [https://pdbe.org/1ztu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ztu RCSB], [https://www.ebi.ac.uk/pdbsum/1ztu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ztu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPHY_DEIRA BPHY_DEIRA] Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Has also a slight blue shift for the far-red maximum. Could also absorb green light. May participate in regulating pigment synthesis like the carotenoid deinoxanthin which could protect the bacterium from intense visible light.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1ztu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ztu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phytochromes are red/far-red light photoreceptors that direct photosensory responses across the bacterial, fungal and plant kingdoms. These include photosynthetic potential and pigmentation in bacteria as well as chloroplast development and photomorphogenesis in plants. Phytochromes consist of an amino-terminal region that covalently binds a single bilin chromophore, followed by a carboxy-terminal dimerization domain that often transmits the light signal through a histidine kinase relay. Here we describe the three-dimensional structure of the chromophore-binding domain of Deinococcus radiodurans phytochrome assembled with its chromophore biliverdin in the Pr ground state. Our model, refined to 2.5 A resolution, reaffirms Cys 24 as the chromophore attachment site, locates key amino acids that form a solvent-shielded bilin-binding pocket, and reveals an unusually formed deep trefoil knot that stabilizes this region. The structure provides the first three-dimensional glimpse into the photochromic behaviour of these photoreceptors and helps to explain the evolution of higher plant phytochromes from prokaryotic precursors.
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===Structure of the chromophore binding domain of bacterial phytochrome===
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A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome.,Wagner JR, Brunzelle JS, Forest KT, Vierstra RD Nature. 2005 Nov 17;438(7066):325-31. PMID:16292304<ref>PMID:16292304</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16292304}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ztu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16292304 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16292304}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZTU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTU OCA].
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==Reference==
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<ref group="xtra">PMID:16292304</ref><references group="xtra"/>
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Brunzelle, J S.]]
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[[Category: Large Structures]]
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[[Category: Forest, K T.]]
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[[Category: Brunzelle JS]]
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[[Category: Vierstra, R D.]]
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[[Category: Forest KT]]
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[[Category: Wagner, J R.]]
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[[Category: Vierstra RD]]
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[[Category: Bacteriophytochrome]]
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[[Category: Wagner JR]]
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[[Category: Biliverdin ix]]
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[[Category: Chromophore]]
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[[Category: Gaf]]
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[[Category: Knot]]
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[[Category: Pa]]
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[[Category: Phytochrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:10:05 2009''
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Current revision

Structure of the chromophore binding domain of bacterial phytochrome

PDB ID 1ztu

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OCA

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