2dde
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2dde" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dde" /> '''Structure of cinnamycin complexed with lysop...) |
|||
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dde" /> | ||
| - | '''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''<br /> | ||
| - | == | + | ==Structure of cinnamycin complexed with lysophosphatidylethanolamine== |
| - | The three-dimensional structure of a complex of cinnamycin, a 19-amino | + | <StructureSection load='2dde' size='340' side='right'caption='[[2dde]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2dde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DDE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BH2:(3R)-3-HYDROXY-L-ASPARTIC+ACID'>BH2</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=LSP:(7S)-4,7-DIHYDROXY-10-OXO-3,5,9-TRIOXA-4-PHOSPHAUNDECAN-1-AMINIUM+4-OXIDE'>LSP</scene>, <scene name='pdbligand=PRD_000195:Cinnamycin'>PRD_000195</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dde OCA], [https://pdbe.org/2dde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dde RCSB], [https://www.ebi.ac.uk/pdbsum/2dde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dde ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CINA_STRGV CINA_STRGV] Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide. | ||
| - | + | Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1.,Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K J Biochem. 1996 Feb;119(2):226-30. PMID:8882709<ref>PMID:8882709</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 2dde" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Streptomyces griseoverticillatus]] | [[Category: Streptomyces griseoverticillatus]] | ||
| - | [[Category: Endo | + | [[Category: Endo S]] |
| - | [[Category: Hosoda | + | [[Category: Hosoda K]] |
| - | [[Category: Kohno | + | [[Category: Kohno T]] |
| - | [[Category: Maeda | + | [[Category: Maeda T]] |
| - | [[Category: Ohya | + | [[Category: Ohya M]] |
| - | [[Category: Wakamatsu | + | [[Category: Wakamatsu K]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of cinnamycin complexed with lysophosphatidylethanolamine
| |||||||||||
