1bxt

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{{Seed}}
 
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[[Image:1bxt.png|left|200px]]
 
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==STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES==
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The line below this paragraph, containing "STRUCTURE_1bxt", creates the "Structure Box" on the page.
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<StructureSection load='1bxt' size='340' side='right'caption='[[1bxt]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bxt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxt OCA], [https://pdbe.org/1bxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxt RCSB], [https://www.ebi.ac.uk/pdbsum/1bxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxt ProSAT]</span></td></tr>
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{{STRUCTURE_1bxt| PDB=1bxt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q54971_STRPY Q54971_STRPY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bxt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcal superantigen (SSA) is a 28,000 Mr toxin originally isolated from a pathogenic strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal enterotoxin B (SEB). SSA and SEB, however, do not compete for binding on the surfaces of cells expressing MHC class II molecules. This behavior had been ascribed to SSA and SEB binding to distinct sites on, or different subsets of, HLA-DR molecules. Here we demonstrate that SSA binds predominantly to HLA-DQ, rather than to HLA-DR molecules, and present the crystal structure of SSA at 1.85 A resolution. These data provide a structural basis for interpreting the interaction of SSA with HLA-DQ molecules as well as a foundation for understanding bacterial superantigen affinities for distinct MHC isotypes.
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===STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES===
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Structural basis for HLA-DQ binding by the streptococcal superantigen SSA.,Sundberg E, Jardetzky TS Nat Struct Biol. 1999 Feb;6(2):123-9. PMID:10048922<ref>PMID:10048922</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10048922}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1bxt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10048922 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10048922}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1BXT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXT OCA].
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==Reference==
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<ref group="xtra">PMID:10048922</ref><references group="xtra"/>
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Jardetzky, T.]]
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[[Category: Jardetzky T]]
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[[Category: Sundberg, E.]]
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[[Category: Sundberg E]]
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[[Category: Bacterial superantigen]]
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[[Category: Mhc class ii interaction]]
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[[Category: T cell activation]]
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[[Category: Toxic shock-like syndrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:23:56 2009''
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Current revision

STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES

PDB ID 1bxt

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