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2vzn

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{{Seed}}
 
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[[Image:2vzn.png|left|200px]]
 
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==Crystal structure of the major allergen from fire ant venom, Sol i 3==
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The line below this paragraph, containing "STRUCTURE_2vzn", creates the "Structure Box" on the page.
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<StructureSection load='2vzn' size='340' side='right'caption='[[2vzn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Solenopsis_invicta Solenopsis invicta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzn OCA], [https://pdbe.org/2vzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzn RCSB], [https://www.ebi.ac.uk/pdbsum/2vzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzn ProSAT]</span></td></tr>
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{{STRUCTURE_2vzn| PDB=2vzn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VA3_SOLIN VA3_SOLIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vzn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vzn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fire ant venom is an extremely potent allergy-inducing agent containing four major allergens, Sol i 1 to Sol i 4, which are the most frequent cause of hypersensitivity reactions to hymenoptera in the southern USA. The crystal structure of recombinant (Baculovirus) major fire ant allergen Sol i 3 has been determined to a resolution of 3.1 A by the method of molecular replacement. The secondary-structure elements of Sol i 3 are arranged in an alpha-beta-alpha sandwich fold consisting of a central antiparallel beta-sheet surrounded on both sides by alpha helices. The overall structure is very similar to that of the homologous wasp venom allergen Ves v 5 with major differences occurring in the solvent-exposed loop regions that contain amino acid insertions. Consequently, the limited conservation of surface chemical properties and topology between Sol i 3 and Ves v 5 may explain the observed lack of relevant cross-reactivity. It is concluded that Sol i 3 recognizes immunoglobulin E antibodies with a distinct set of its own epitopes, which are different from those of Ves v 5. Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes.
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===CRYSTAL STRUCTURE OF THE MAJOR ALLERGEN FROM FIRE ANT VENOM, SOL I 3===
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Crystal structure of the major allergen from fire ant venom, Sol i 3.,Padavattan S, Schmidt M, Hoffman DR, Markovic-Housley Z J Mol Biol. 2008 Oct 31;383(1):178-85. Epub 2008 Aug 22. PMID:18761353<ref>PMID:18761353</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18761353}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vzn" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18761353 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_18761353}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2VZN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Solenopsis_invicta Solenopsis invicta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA].
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==Reference==
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<ref group="xtra">PMID:18761353</ref><references group="xtra"/>
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[[Category: Solenopsis invicta]]
[[Category: Solenopsis invicta]]
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[[Category: Markovic-Housley, Z.]]
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[[Category: Markovic-Housley Z]]
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[[Category: Padavattan, S.]]
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[[Category: Padavattan S]]
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[[Category: Allergen]]
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[[Category: Cross- reactivity]]
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[[Category: Major fire ant allergen]]
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[[Category: Secreted]]
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[[Category: Sol i 3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:07 2009''
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Current revision

Crystal structure of the major allergen from fire ant venom, Sol i 3

PDB ID 2vzn

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