2dk8

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(New page: 200px<br /><applet load="2dk8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dk8" /> '''Solution structure of rpc34 subunit in RNA p...)
Current revision (18:42, 29 May 2024) (edit) (undo)
 
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[[Image:2dk8.gif|left|200px]]<br /><applet load="2dk8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dk8" />
 
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'''Solution structure of rpc34 subunit in RNA polymerase III from mouse'''<br />
 
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==About this Structure==
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==Solution structure of rpc34 subunit in RNA polymerase III from mouse==
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2DK8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DK8 OCA].
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<StructureSection load='2dk8' size='340' side='right'caption='[[2dk8]]' scene=''>
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[[Category: DNA-directed RNA polymerase]]
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== Structural highlights ==
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[[Category: Mus musculus]]
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<table><tr><td colspan='2'>[[2dk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DK8 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: He, F.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dk8 OCA], [https://pdbe.org/2dk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dk8 RCSB], [https://www.ebi.ac.uk/pdbsum/2dk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dk8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dk8 TOPSAN]</span></td></tr>
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[[Category: Inoue, M.]]
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</table>
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[[Category: Kigawa, T.]]
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== Function ==
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[[Category: Muto, Y.]]
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[https://www.uniprot.org/uniprot/RPC6_MOUSE RPC6_MOUSE] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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== Evolutionary Conservation ==
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[[Category: Shirouzu, M.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Terada, T.]]
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Check<jmol>
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[[Category: Yokoyama, S.]]
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<jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dk8_consurf.spt"</scriptWhenChecked>
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[[Category: nmr]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: nppsfa]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: riken structural genomics/proteomics initiative]]
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</jmolCheckbox>
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[[Category: rna polymerase iii c39 subunit]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dk8 ConSurf].
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[[Category: rna_pol_rpc34 domain]]
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<div style="clear:both"></div>
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:38:16 2007''
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: He F]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Muto Y]]
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[[Category: Shirouzu M]]
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[[Category: Terada T]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of rpc34 subunit in RNA polymerase III from mouse

PDB ID 2dk8

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