1spg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:53, 17 October 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1spg.png|left|200px]]
 
-
<!--
+
==CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS==
-
The line below this paragraph, containing "STRUCTURE_1spg", creates the "Structure Box" on the page.
+
<StructureSection load='1spg' size='340' side='right'caption='[[1spg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1spg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiostomus_xanthurus Leiostomus xanthurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-
{{STRUCTURE_1spg| PDB=1spg | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spg OCA], [https://pdbe.org/1spg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spg RCSB], [https://www.ebi.ac.uk/pdbsum/1spg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spg ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HBA_LEIXA HBA_LEIXA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spg ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The remarkable ability of root effect haemoglobins to pump oxygen against high O2 gradients results from extreme, acid-induced reductions in O2 affinity and cooperativity. The long-sought mechanism for the root effect, revealed by the 2 angstrom crystal structure of the ligand-bound haemoglobin from Leiostomus xanthurus at pH 7.5, unexpectedly involves modulation of the R-state. Key residues strategically assemble positive-charge clusters across the allosteric beta1 beta2-interface in the R-state. At low pH, protonation of the beta N terminus and His 147(HC3)beta within these clusters is postulated to destabilize the R-state and promote the acid-triggered, allosteric R--&gt;T switch with concomitant O2 release. Surprisingly, a set of residues specific to root effect haemoglobins recruit additional residues, conserved among most haemoglobins, to produce the root effect.
-
===CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS===
+
Structural basis for the root effect in haemoglobin.,Mylvaganam SE, Bonaventura C, Bonaventura J, Getzoff ED Nat Struct Biol. 1996 Mar;3(3):275-83. PMID:8605630<ref>PMID:8605630</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1spg" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_8605630}}, adds the Publication Abstract to the page
+
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 8605630 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_8605630}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1SPG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Leiostomus_xanthurus Leiostomus xanthurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPG OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:8605630</ref><references group="xtra"/>
+
[[Category: Leiostomus xanthurus]]
[[Category: Leiostomus xanthurus]]
-
[[Category: Getzoff, E D.]]
+
[[Category: Getzoff ED]]
-
[[Category: Mylvaganam, S E.]]
+
[[Category: Mylvaganam SE]]
-
[[Category: Carbon monoxide]]
+
-
[[Category: Globin]]
+
-
[[Category: Leiostomus xanthurus]]
+
-
[[Category: Oxygen transport]]
+
-
[[Category: R-state]]
+
-
[[Category: Root effect]]
+
-
[[Category: Teleost fish]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:47:09 2009''
+

Current revision

CARBONMONOXY HEMOGLOBIN FROM THE TELEOST FISH LEIOSTOMUS XANTHURUS

PDB ID 1spg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1spg"
Personal tools