1r2b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:19, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1r2b.png|left|200px]]
 
-
<!--
+
==Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide==
-
The line below this paragraph, containing "STRUCTURE_1r2b", creates the "Structure Box" on the page.
+
<StructureSection load='1r2b' size='340' side='right'caption='[[1r2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1r2b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2B FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2b OCA], [https://pdbe.org/1r2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2b RCSB], [https://www.ebi.ac.uk/pdbsum/1r2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2b ProSAT]</span></td></tr>
-
{{STRUCTURE_1r2b| PDB=1r2b | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2b ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===
+
==See Also==
-
 
+
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-
 
+
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_14690607}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 14690607 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_14690607}}
+
-
 
+
-
==Disease==
+
-
Known disease associated with this structure: Lymphoma, B-cell OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109565 109565]]
+
-
 
+
-
==About this Structure==
+
-
1R2B is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:14690607</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ahmad, K F.]]
+
[[Category: Large Structures]]
-
[[Category: Bouchard, D.]]
+
[[Category: Ahmad KF]]
-
[[Category: Kiang, C L.]]
+
[[Category: Bouchard D]]
-
[[Category: Lax, S A.]]
+
[[Category: Kiang CL]]
-
[[Category: Licht, J D.]]
+
[[Category: Lax SA]]
-
[[Category: Liu, J.]]
+
[[Category: Licht JD]]
-
[[Category: Mayer, S.]]
+
[[Category: Liu J]]
-
[[Category: Melnick, A.]]
+
[[Category: Mayer S]]
-
[[Category: Prive, G G.]]
+
[[Category: Melnick A]]
-
[[Category: B-cell lymphoma]]
+
[[Category: Prive GG]]
-
[[Category: Btb domain]]
+
-
[[Category: Hdac complex]]
+
-
[[Category: Transcriptional repression]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:50:39 2009''
+

Current revision

Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide

PDB ID 1r2b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r2b"
Personal tools