This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1s5p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:29, 1 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1s5p.png|left|200px]]
 
-
<!--
+
==Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.==
-
The line below this paragraph, containing "STRUCTURE_1s5p", creates the "Structure Box" on the page.
+
<StructureSection load='1s5p' size='340' side='right'caption='[[1s5p]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1s5p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5P FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1s5p| PDB=1s5p | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5p OCA], [https://pdbe.org/1s5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5p RCSB], [https://www.ebi.ac.uk/pdbsum/1s5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5p ProSAT]</span></td></tr>
-
 
+
</table>
-
===Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NPD_ECOLI NPD_ECOLI] NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes.<ref>PMID:10811920</ref> <ref>PMID:24176774</ref> <ref>PMID:15019790</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_15019790}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15019790 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5p_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_15019790}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1S5P is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5P OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5p ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:15019790</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Chai, X.]]
+
[[Category: Large Structures]]
-
[[Category: Marmorstein, R.]]
+
[[Category: Chai X]]
-
[[Category: Zhao, K.]]
+
[[Category: Marmorstein R]]
-
[[Category: Protein deacetylase]]
+
[[Category: Zhao K]]
-
[[Category: Sir2 homologue]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:01:59 2009''
+

Current revision

Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli.

PDB ID 1s5p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s5p"
Personal tools