1qgv

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{{Seed}}
 
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[[Image:1qgv.png|left|200px]]
 
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==HUMAN SPLICEOSOMAL PROTEIN U5-15KD==
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The line below this paragraph, containing "STRUCTURE_1qgv", creates the "Structure Box" on the page.
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<StructureSection load='1qgv' size='340' side='right'caption='[[1qgv]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QGV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qgv OCA], [https://pdbe.org/1qgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qgv RCSB], [https://www.ebi.ac.uk/pdbsum/1qgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qgv ProSAT]</span></td></tr>
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{{STRUCTURE_1qgv| PDB=1qgv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qg/1qgv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qgv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The U5 small ribonucleoprotein particle (snRNP) contains various proteins involved in catalytic activities mediating conformational rearrangements of the spliceosome. We have isolated and characterized the evolutionarily highly conserved human U5 snRNP-specific protein U5-15kD. The crystal structure of U5-15kD determined at 1.4 A resolution revealed a thioredoxin-like fold and represents the first structure of a U5 snRNP-specific protein known so far. With respect to human thioredoxin the U5-15kD protein contains 37 additional residues causing structural changes which most likely form putative binding sites for other spliceosomal proteins or RNA. Moreover, a novel intramolecular disulfide bond replaces the canonical one found in the thioredoxin family. Even though U5-15kD appears to lack protein disulfide isomerase activity, it is strictly required for pre-mRNA splicing in vivo as we demonstrate by genetic depletion of its ortholog in Saccharomyces cerevisiae. Our data suggest that the previously reported involvement of its Schizosaccharomyces pombe ortholog Dim1p in cell cycle regulation is a consequence of its essential role in pre-mRNA splicing.
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===HUMAN SPLICEOSOMAL PROTEIN U5-15KD===
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Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.,Reuter K, Nottrott S, Fabrizio P, Luhrmann R, Ficner R J Mol Biol. 1999 Nov 26;294(2):515-25. PMID:10610776<ref>PMID:10610776</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qgv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10610776}}, adds the Publication Abstract to the page
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*[[U5-15kD|U5-15kD]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10610776 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10610776}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1QGV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QGV OCA].
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==Reference==
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<ref group="xtra">PMID:10610776</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fabrizio, P.]]
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[[Category: Large Structures]]
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[[Category: Ficner, R.]]
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[[Category: Fabrizio P]]
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[[Category: Luehrmann, R.]]
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[[Category: Ficner R]]
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[[Category: Nottrott, S.]]
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[[Category: Luehrmann R]]
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[[Category: Reuter, K.]]
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[[Category: Nottrott S]]
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[[Category: Snrnp]]
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[[Category: Reuter K]]
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[[Category: Spliceosomal protein]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:02:43 2009''
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Current revision

HUMAN SPLICEOSOMAL PROTEIN U5-15KD

PDB ID 1qgv

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