1x99

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:00, 17 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1x99.png|left|200px]]
 
-
<!--
+
==X-ray crystal structure of Xerocomus chrysenteron lectin XCL at 1.4 Angstroms resolution, mutated at Q46M, V54M, L58M==
-
The line below this paragraph, containing "STRUCTURE_1x99", creates the "Structure Box" on the page.
+
<StructureSection load='1x99' size='340' side='right'caption='[[1x99]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1x99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xerocomellus_chrysenteron Xerocomellus chrysenteron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X99 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1x99| PDB=1x99 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x99 OCA], [https://pdbe.org/1x99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x99 RCSB], [https://www.ebi.ac.uk/pdbsum/1x99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x99 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8WZC9_9AGAM Q8WZC9_9AGAM]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x99_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x99 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
A newly defined family of fungal lectins displays no significant sequence similarity to any protein in the databases. These proteins, made of about 140 amino acid residues, have sequence identities ranging from 38% to 65% and share binding specificity to N-acetyl galactosamine. One member of this family, the lectin XCL from Xerocomus chrysenteron, induces drastic changes in the actin cytoskeleton after sugar binding at the cell surface and internalization, and has potent insecticidal activity. The crystal structure of XCL to 1.4 A resolution reveals the architecture of this new lectin family. The fold of the protein is not related to any of the several lectin folds documented so far. Unexpectedly, the structure similarity is significant with actinoporins, a family of pore-forming toxins. The specific structural features and sequence signatures in each protein family suggest a potential sugar binding site in XCL and a possible evolutionary relationship between these proteins. Finally, the tetrameric assembly of XCL reveals a complex network of protomer-protomer interfaces and generates a large, hydrated cavity of 1000 A3, which may become accessible to larger solutes after a small conformational change of the protein.
-
===X-ray crystal structure of Xerocomus chrysenteron lectin XCL at 1.4 Angstroms resolution, mutated at Q46M, V54M, L58M===
+
A new lectin family with structure similarity to actinoporins revealed by the crystal structure of Xerocomus chrysenteron lectin XCL.,Birck C, Damian L, Marty-Detraves C, Lougarre A, Schulze-Briese C, Koehl P, Fournier D, Paquereau L, Samama JP J Mol Biol. 2004 Dec 10;344(5):1409-20. PMID:15561152<ref>PMID:15561152</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15561152}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1x99" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15561152 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_15561152}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1X99 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Xerocomus_chrysenteron Xerocomus chrysenteron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X99 OCA].
+
[[Category: Xerocomellus chrysenteron]]
-
 
+
[[Category: Birck C]]
-
==Reference==
+
[[Category: Damian L]]
-
<ref group="xtra">PMID:15561152</ref><references group="xtra"/>
+
[[Category: Fournier D]]
-
[[Category: Xerocomus chrysenteron]]
+
[[Category: Koehl P]]
-
[[Category: Birck, C.]]
+
[[Category: Lougarre A]]
-
[[Category: Damian, L.]]
+
[[Category: Marty-Detraves C]]
-
[[Category: Fournier, D.]]
+
[[Category: Paquereau L]]
-
[[Category: Koehl, P.]]
+
[[Category: Samama JP]]
-
[[Category: Lougarre, A.]]
+
[[Category: Schulze-Briese C]]
-
[[Category: Marty-Detraves, C.]]
+
-
[[Category: Paquereau, L.]]
+
-
[[Category: Samama, J P.]]
+
-
[[Category: Schulze-Briese, C.]]
+
-
[[Category: Fungal lectin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:10:25 2009''
+

Current revision

X-ray crystal structure of Xerocomus chrysenteron lectin XCL at 1.4 Angstroms resolution, mutated at Q46M, V54M, L58M

PDB ID 1x99

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x99"
Personal tools