1nm7

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{{Seed}}
 
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[[Image:1nm7.png|left|200px]]
 
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==Solution structure of the ScPex13p SH3 domain==
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The line below this paragraph, containing "STRUCTURE_1nm7", creates the "Structure Box" on the page.
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<StructureSection load='1nm7' size='340' side='right'caption='[[1nm7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nm7 OCA], [https://pdbe.org/1nm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1nm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nm7 ProSAT]</span></td></tr>
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{{STRUCTURE_1nm7| PDB=1nm7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEX13_YEAST PEX13_YEAST] Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nm/1nm7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nm7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pex13p is an essential component of the peroxisomal protein import machinery and interacts via its C-terminal SH3 domain with the type II SH3-ligand Pex14p and the non-PXXP protein Pex5p. We report the solution structure of the SH3 domain of Pex13p from Saccharomyces cerevisiae and the identification of a novel-binding pocket, which binds a non-PXXP-peptide representing the binding site of Pex5p. Chemical shift assays revealed the binding sites for Pex5p and Pex14p ligand peptides to be distinct and spatially separated. Competition assays demonstrated that the two ligand peptides can bind simultaneously to the SH3 domain.
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===Solution structure of the ScPex13p SH3 domain===
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The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p.,Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:12595255<ref>PMID:12595255</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12595255}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1nm7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12595255 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12595255}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1NM7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA].
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==Reference==
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<ref group="xtra">PMID:12595255</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Brockmann, C.]]
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[[Category: Brockmann C]]
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[[Category: Erdmann, R.]]
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[[Category: Erdmann R]]
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[[Category: Hong, X.]]
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[[Category: Hong X]]
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[[Category: Oschkinat, H.]]
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[[Category: Oschkinat H]]
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[[Category: Pires, J R.]]
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[[Category: Pires JR]]
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[[Category: Schneider-Mergener, J.]]
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[[Category: Schneider-Mergener J]]
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[[Category: Volkmer-Engert, R.]]
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[[Category: Volkmer-Engert R]]
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[[Category: Import machine]]
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[[Category: Membrane protein]]
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[[Category: Pex13p]]
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[[Category: Pex14p]]
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[[Category: Pex5p]]
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[[Category: Sh3 domain]]
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[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:11:13 2009''
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Current revision

Solution structure of the ScPex13p SH3 domain

PDB ID 1nm7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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